化痰通络方对急性脑梗死患者血清脑源性神经营养因子及神经生长因子水平的影响

目的探讨化痰通络方治疗急性脑梗死临床疗效及其对患者血清脑源性神经营养因子（BDNF）及神经生长因子（NGF）水平的影响。方法选取急性脑梗死患者120例按就诊顺序分为观察组与对照组,每组60例。对照组予以单纯西医常规治疗,观察组在对照组基础上加用化痰通络方,15天为1个疗程,两组均治疗2个疗程。治疗前、后评价两组神经功能缺损评分（NIHSS）,观察临床疗效,检测血清BDNF、NGF水平,监测药物不良反应。结果治疗前,两组NIHSS评分、血清BDNF和NGF水平比较,差异均无统计学意义（P〉0.05）；治疗后,两组NIHSS评分均降低（P〈0.05,P〈0.01）,血清BDNF、NGF水平均升高（P〈0.05）；观察组NIHSS评分低于对照组（P〈0.05）,BDNF、NGF水平均高于对照组（P〈0.05）。观察组与对照组总有效率分别为93.33%、78.33%,差异有统计学意义（P〈0.05）。除观察组1例患者轻微皮肤症状外,均未见其他药物不良反应。结论化痰通络方治疗急性脑梗死可显著提高患者血清BDNF和NGF水平,改善神经功能缺损程度,疗效优于单纯西药治疗,且未见明显不良反应。

Effect of Huatan Tongluo Fang on Brain-derived Neurotrophic Factor and Nerve Growth Factor of Pa-tients with Acute Cerebral Infarction

Objective To investigate the therapeutic effect of Huatan Tongluo Fang on acute cerebral infarction （ACI） and its effect on the levels of brain-derived neurotrophic factor （BDNF） and nerve growth factor （NGF） of ACI patients. Methods One hundred and twenty ACI patients were assigned to observation group or control group according to their admission order. Control group was given conventional western medicine. Observation group was given western medicine plus Huatan Tongluo Fang. Both groups finished two courses of treatment,15 days in one course. NIHSS was assessed before and after treatment to evaluate the clinical efficacy. The levels of serum BDNF and NGF were detected. Adverse events were recorded. Results No significant difference in NIHSS,and levels of serum BDNF and NGF was noted between two groups before treatment （P〉0.05）. After treatment,NIHSS decreased in both groups（P〈0.05,P〈0.01）,but the levels of serum BDNF and NGF were increased（Ps〈0.05）;NIHSS in obser-vation group was lower than that in control group （P〈0.05）,but the levels of serum BDNF and NGF in observation group was higher than that in control group （Ps〈0.05）. The therapeutic efficacy was achieved to 93.33% in obser-vation group and 78.33% in control group,with a significant difference（P〈0.05）. Only one case of mild skin symp-tom occurred in observation group. Conclusion Huatan Tongluo Fang may be benefit to ACI patients by elevating levels of serum BDNF and NGF. It has better outcome than western medicine does and does not increase adverse events.