2型糖尿病足部自主神经病变与C肽水平的相关性研究

【摘要】目的 探讨C肽水平与2型糖尿病（T2DM）足部自主神经病变的关系。方法 检测124例T2DM患者的空腹血糖（FBG）、餐后2h血糖（2h-PG）、空腹C肽（FC-P），利用欧米诺诊断膏贴测定足部神经泌汗功能，根据患者足部神经泌汗功能检查结果，分为糖尿病自主神经病变（DAN）组及非自主神经病变（NDAN）组，比较2组性别、年龄、体质指数、血压、FBG、2h-PG、FC-P水平。将欧米诺诊断膏贴完全变色时间与上述指标进行Pearson相关分析。结果 2组患者性别、年龄、FBG、2h-PG比较差异无统计学意义（P＞0.05），DAN组患者FC-P水平为（1.07±0.75） nmol/L，低于NDAN组的（1.43±1.00）nmol/L（P＜0.05）。糖尿病足部欧米诺诊断膏贴变色时间与C肽呈负相关。结论 T2DM患者足部自主神经功能与C肽密切相关，推测C肽可能对足部自主神经具有保护性作用。

The Correlation Analysis between C-Peptide Level and Autonomic Neuropathy in Type2Diabetic Patients

[Abstract] Objective Todiscuss the correlation between C- peptide level and autonomic neuropathy in diabetic foot in patients with type 2diabetes mellitus (T2DM).Methods The levels of fasting blood glucose (FBG),2h postprandial blood glucose (2h-PG) and fasting C-peptide (FC-P) were detected in124T2DM patients. The Neuropad was used to test functions of sudomotor nerves in foot. Patients were divided into two groups: diabetic autonomic neuropathy (DAN) group and non-autonomic neuropathy group (NDAN) according to the results of functions of sudomotor nerves in foot. Values of gender, age, body mass index (BMI), blood pressure, FBG,2h-PG and FC-P were compared between the two groups. The Pearson correlation analysis was carried out between the indexes mentioned above and the time for completing color change of Neuro? pad.Results There were no significant differences in gender, age, FBG and2h-PG between two groups (P>0.05). The FC- P level was (1.07±0.75)nmol/L in DAN group, which was significantly lower than that in NDAN group (1.43±1.00) nmol/L (P>0.05). The time for completing color change of Neuropad was negatively correlated with C- peptide. Conclu? sion Theautonomic nerve functions in diabetic foot is closely related with C-peptide. It is inferred that C-peptide may have protective effect on autonomic nerves in diabetic foot.