Molecular targeted therapy for breast cancer patients based on Notch signal transduction pathway

Studied show that the Notch signal transduction pathway involves in the regulation and control of cell proliferation, differentiation and apoptosis. Aberrant Notch signaling can induce breast cancer in transgenic mice. High expressions of either Notch receptors or their ligands have been linked to poor prognosis in patients with breast cancer. Inhibition of Notch signal transduction pathway may be beneficial for breast cancer treatment.