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Application of tumor markers in diagnosis and prognosis assessment of pancreatic carcinoma.

??Abstract??Objective To investigate the roles of tumor markers in diagnosis and prognosis assessment of patients with pancreatic carcinoma.Methods We collected 198 cases of pancreatic carcinoma??50 cases of benign pancreatic diseases and 61 cases of normal controls.Radioimmunoassay was used to detect the tumor markers such as CA19-9??CA242??CA125??CA50 and CEA.A total of 120 cases of pancreatic carcinoma were followed up and the factors influencing their prognosis were analyzed.Results The average levels of CA19-9??CA242 and CA125 in pancreatic carcinoma cases were significantly higher than those in the controls and benign pancreatic disease cases (P<0.05).We obtained sensitivities of 80.84%??72.50%??56.67%??56.12% and 45.31% for CA19-9??CA242??CA125??CA50 and CEA??respectively??and specificities of 76.80%??69.32%??72.96 %??65.33% and 57.40% for CA19-9??CA242??CA125??CA50 and CEA??respectively.Combined detection increased the sensitivity but reduced the specificity.The median survival time of the pancreatic cancer patients was 5.5 months.Patients with tumors located at pancreatic body??tail and the whole pancreas had less survival time than those with tumors located at pancreatic head and neck.Patients with higher levels of CA19-9??CA242 and CA125 had less survival time (P<0.05).Cox multivariate proportional hazards model showed that CA19-9 and CA242 were independent prognostic factors (P<0.05).Conclusion Early diagnosis of pancreatic carcinoma depends on serum examinations of tumor marker.Combined detection increases the sensitivity and reduces the specificity of the markers.Patients with tumor located at the pancreatic body??pancreatic tail??and with higher levels of CA19-9??CA242 and CA125 may have less survival time.CA19-9 and CA242 are independent prognostic factors that may help to assess the prognosis of pancreatic carcinoma.