紧密连接在妊娠生理与病理生理中的作用

紧密连接（tight junction，TJ）主要由跨膜蛋白家族occludin，claudin以及膜周蛋白ZO家族等构成，存在于上皮细胞之间、上皮细胞与血管内皮细胞之间，负责调控细胞旁离子和溶质分子的跨膜运输及维持细胞极性状态，参与细胞分化增殖等重要生理功能，受到多种因素调节。研究显示，正常子宫内膜组织、胎盘组织以及黄体细胞中均有紧密连接结构和紧密连接相关因子的表达，紧密连接结构和功能异常可影响妊娠期子宫内膜容受性、胎盘植入及黄体功能，可能参与妊娠生理过程和妊娠病理生理的发生发展。因此，研究紧密连接在妊娠生理和病理中的作用具有重要的意义。

Roles of Tight Junction in Normal and Pathological Pregnancy

Tight junction is a fundamental junctional complex of the adjacent epithelial cells consist of several protein families such as transmembrane proteins occludin，claudin and peripheral proteins ZOs. Tight junction performs specialized functions including maintenance of paracellular barrier functions and cell polarity principally. The structure and function of tight junction can bechanged by some physio-/pathological factors. Tight junction has already been detected in human uterine endometrium，placenta and luteal cells. Abnormality of tight junction may correlate with endometrial receptivity，placental implantation and luteal function and also has been involved in the pregnancy complications.