| 组蛋白修饰酶与子宫内膜癌发生发展关系的研究进展 |
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| 引用本文： | 李 清,冯炜炜. 组蛋白修饰酶与子宫内膜癌发生发展关系的研究进展[J]. 国际妇产科学杂志, 2013, 40(3): 244-246 |
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| 作者姓名： | 李 清 冯炜炜 |
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| 作者单位： | 200011 上海，复旦大学附属妇产科医院 |
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| 摘 要： | 表观遗传学是研究没有细胞核DNA序列改变的情况时基因功能可逆的、可遗传的改变。这些改变包括DNA甲基化、组蛋白修饰、微小RNA（micro RNA）和基因组印迹等。组蛋白是核小体的关键成分，组蛋白修饰在遗传学中意义重大。组蛋白修饰酶与人类肿瘤的关系日渐成为研究热点，而在子宫内膜癌领域相关研究较少。现对近5年来相关文献进行汇总，从组蛋白乙酰化、组蛋白甲基化、组蛋白修饰与DNA甲基化关系三个方面着手，阐述组蛋白修饰酶与子宫内膜癌的研究进展。
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| 关 键 词： | 子宫内膜肿瘤 组蛋白酰基转移酶 DNA甲基化 乙酰化作用 后成说 遗传 |
Relationship between Enzyme of Histone Modifications and Endometrial Cancer |
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| LI Qing,FENG Wei-wei. Relationship between Enzyme of Histone Modifications and Endometrial Cancer[J]. Journal of International Obstetrics and Gynecology, 2013, 40(3): 244-246 |
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| Authors: | LI Qing FENG Wei-wei |
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| Affiliation: | Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200011，China |
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| Abstract: | Epigenetic change consists of DNA methylation，histone modification，Micro RNA，genome imprinting. Histone is the key component of nucleosome，displaying a significant role in epigenetics. Nowadays，the role of histone modification on the carcinogenesis and cancer development becomes a research hot spot. However，the relationship between histone modification and endometrial cancer has not been thoroughly studied. Relevant articles of the past five years were summarized in this article，focusing on histone acetylation，histone methylation，and the relationship between histone modification and DNA methylation in endometrial cancer. |
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| Keywords: | Endometrial neoplasms Histone acetyltransferases DNA methylation Acetylation Epigenesis genetic |
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