| Abstract: | Objective To evaluate the effect of dialysate interleukin-6 (IL-6), a marker of ongoing peritoneal inflammation, on the alteration of peritoneal solute transport rates (PSTRs) in stable continuous ambulatory peritoneal dialysis (CAPD) patients. Methods Atotal of 128 case of stable CAPD patients were enrolled in present study.IL-6 levels in the overnight effluent were determined by ELISA and IL-6 appearance rates (AR) were calculated. Mass transfer area coefficients of creatinine (MTACcr) were prospectively followed up. Logistic regression was used to examine the association between IL-6 AR and increased PSTRs. Results The MTACcr was significantly increased after 12 months follow-up[M(1/4,3/4), 6.40(4.70, 8.75) ml/min vs 7.14(5.59, 8.73) ml/min, P＜0.05]. Compared to the patients with stable PSTRs, the dialysate IL-6 AR in patients with increased PSTRs showed significantly higher [277.08(247.45, 349.53) pg/min vs 263.18 (69.94, 286.72) pg/min, P＜0.05]. Patients with increased PSTRs also had lower residual renal function [0.79(0, 2.12) ml/min vs 1.70 (0.39, 3.38) ml/min, P＜0.05], less urine volume [225(0, 600) ml/24 h vs 500(125, 900) ml/24 h, P＜0.05] and lower baseline MTACcr [5.48 (4.17, 7.42) ml/min vs 7.00(5.46, 9.76) ml/min, P＜0.05] when compared to their counterparts with stable PSTRs. Logistic analysis showed that high dialysate IL-6 AR and low baseline MTACcr were independent risk factors for increasing peritoneal solute transport rate (P＜0.05). Conclusion Intra-peritoneal inflammation significantly affects the alteration of PSTRs, and the dialysate IL-6 may be a predictor for increased PSTRs in PD patients. |
