“代谢记忆”现象与糖尿病视网膜病变

“代谢记忆”现象是指，糖尿病患者发病时，如果高血糖不能及时调整到正常，即使后来血糖持续稳定在正常水平，其慢性并发症（包括视网膜病变）仍然会发生发展，难以逆转。糖尿病视网膜病变是一种常见的糖尿病并发症。现就“代谢记忆”与糖尿病视网膜病变发病的关系、“代谢记忆”现象的产生机制以及抗“代谢记忆”药物等研究状况进行简要综述，以期为糖尿病视网膜病变的防治提供新的策略。

Metabolic memory and diabetic retinopathy

Abundant evidence has established that glycemic control， if not started at a very early stage of diabetes， is not enough to completely reduce its chronic complications， including retinopathy. This phenomenon has recently been defined as “metabolic memory”. Diabetic retinopathy （DR） is one of the common complications. This review summarizes the relationship between the “metabolic memory” phenomenon and DR， the molecular mechanisms for propagating this phenomenon， and potential therapeutic agents to reverse “metabolic memory” in DR， contributing to a future strategy in the prevention and treatment of DR.