| 葎草茎叶石油醚部位化学成分 |
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| 引用本文： | 孙彪,敖运林,王德智,王俊雅,叶文才,张晓琦. 葎草茎叶石油醚部位化学成分[J]. 中国药科大学学报, 2022, 53(2): 178-184 |
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| 作者姓名： | 孙彪 敖运林 王德智 王俊雅 叶文才 张晓琦 |
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| 作者单位： | 暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632,暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632,暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632,暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632,暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632;国家药品监督管理局中成药质量评价重点实验室，广州 510632,暨南大学药学院中药及天然药物研究所，广州 510632;暨南大学广东省现代中药工程技术研究中心，广州 510632;国家药品监督管理局中成药质量评价重点实验室，广州 510632 |
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| 基金项目： | 国家自然科学基金资助项目（No.U1801287，No.82073712）；广东省科技计划资助项目（No.2020B1111110004）；广州市科技计划资助项目（No.20212210005） |
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| 摘 要： | 研究桑科葎草（Humulus scandens）茎叶石油醚部位化学成分。采用硅胶、Sephadex LH-20、ODS、制备型高效液相等色谱方法进行分离纯化，从桑科中药葎草（Humulus scandens）茎叶中分离得到15个化合物，应用理化数据和波谱学方法分别鉴定为杨芽黄素（1）、白杨素（2）、5-羟基-3,4’,6,7-四甲氧基黄酮（3）、（2S）-5-羟基-7,8-二甲氧基二氢黄酮（4）、欧前胡素（5）、珊瑚菜内酯（6）、4-羟基-3-(3’-甲基-2’-丁烯基)苯甲酸乙酯（7）、对羟基苯丙酸（8）、反式对羟基肉桂酸乙酯（9）、对羟基苯甲醛（10）、anofinic acid(11)、5,6-去氢卡文内酯（12）、大黄素甲醚（13）、齐墩果-12-烯-3,11-二酮（14）、ergosta-4,6,8(14),22-tetraen-3-one(15)，以上化合物均为首次从该植物中分离得到。
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| 关 键 词： | 桑科 葎草 化学成分 黄酮 |
| 收稿时间： | 2021-08-27 |
| 修稿时间： | 2022-03-01 |
Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens |
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| SUN Biao,AO Yunlin,WANG Dezhi,WANG Juny,YE Wencai and ZHANG Xiaoqi. Chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens[J]. Journal of China Pharmaceutical University, 2022, 53(2): 178-184 |
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| Authors: | SUN Biao AO Yunlin WANG Dezhi WANG Juny YE Wencai ZHANG Xiaoqi |
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| Affiliation: | Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632,Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632,Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632,Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632,Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632;NMPA Key Laboratory for Quality Evaluation of TCM, Guangzhou 510632, China,Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Ji''nan University, Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM, Ji'' nan University, Guangzhou 510632;NMPA Key Laboratory for Quality Evaluation of TCM, Guangzhou 510632, China |
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| Abstract: | To study the chemical constituents of petroleum ether extract from the stems and leaves of Humulus scandens (family of Moraceae), fifteen compounds were isolated from the stems and leaves of H.scandens by silica gel, Sephadex LH-20, ODS, and preparative HPLC chromatography.The structures were identified by physicochemical data and spectroscopic method as tectochrysin (1), chrysin (2), 5-hydroxy-3, 4'', 6, 7-tetramethoxyflavone (3), (2S)-5-hydroxy-7, 8-dimethoxyflavanone (4), imperatorin (5), phellopterin (6), ethyl 4-hydroxy-3-(3''-methyl-2''-butenyl)benzoate (7), p-hydroxy-phenylpropionic acid (8), ethyl p-hydroxycinnamate (9), p-hydroxybenzaldehyde (10), anofinic acid (11), 5,6-dehydrokavain (12), physcion (13), olean-12-ene-3,?11-dione (14) and ergosta-4, 6, 8 (14), 22-tetraen-3-one (15), respectively.All compounds were isolated from this plant for the first time. |
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| Keywords: | Moraceae Humulus scandens chemical constitutents flavones |
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