Lack of association of the angiotensin converting enzyme gene polymorphism with essential hypertension in a chinese population |
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| Institution: | 1. Programa de Pós-Graduação em Ecologia e Conservação, Universidade Federal do Paraná, Curitiba, Paraná, Brazil;2. Departamento de Biodiversidade, Setor Palotina, Universidade Federal do Paraná Palotina, Paraná, Brazil;3. Laboratório de Ecologia Vegetal, Departamento de Botânica, Universidade Federal do Paraná, Curitiba, Paraná, Brazil;4. Programa de Pós-Graduação em Botânica, Universidade Federal do Paraná, Curitiba, Paraná, Brazil;5. Plant Biology Graduate Program, Instituto de Biologia, Universidade de Campinas, UNICAMP, Campinas, São Paulo, Brazil;6. Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia;7. Ulm University, Institute of Systematic Botany and Ecology, Ulm, Germany;8. Departamento de Biologia Vegetal, Universidade de Campinas, Campinas, Brazil;9. Estonian University of Life Sciences, Kreutzwaldi 1, Tartu 51006, Estonia;10. Programa de Pós-Graduação em Ecologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;11. Embrapa Clima Temperado, Pelotas, Rio Grande do Sul, Brazil;12. Laboratório de Ecologia Funcional de Comunidades (LABEF), Departamento de Botânica, Universidade Federal do Paraná, Curitiba, Paraná, Brazil |
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| Abstract: | To examine the association between insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene and essential hypertension in a Chinese population, a case-control study was conducted using 157 hypertensive and 115 normotensive subjects. The I/D polymorphism of the ACE gene was identified by polymerase chain reaction. Plasma ACE activity was determined using spectrophotometry. The difference of allele frequencies between normotensives and hypertensives was statistically significant (X2 = 4.467, P = .035), while the gentotype distribution was not different between normotensive and hypertensive subjects (X2 = 3.954, P = .138). Plasma ACE activity was highest in the DD genotype, followed by the ID genotype, and the lowest in the II genotype (P = .0001 in normotensives and P = .163 in hypertensives, respectively). Thus, we conclude that the ACE gene polymorphism is not associated with essential hypertension in this Chinese population, but plasma ACE activity is genetically determined in the normotensive Chinese. |
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