Effect of Acute N-Nitro-l-Arginine Methyl Ester (L-NAME) Hypertension on Glucose Tolerance,Insulin Levels,and [3H]-Deoxyglucose Muscle Uptake |
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| Institution: | 1. Hypertension Unit, Department of Medicine, Hadassah University Hospital Mount Scopus, Jerusalem, Israel;2. Department of Medicine, Hadassah University Hospital Ein Kerem, Jerusalem, Israel;1. School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja, 150003, Colombia;2. Faculty of Health Sciences. Universidad de Boyacá, Tunja, 150003, Colombia;1. Facultad de Ciencias Químicas. Universidad Autonoma de Coahuila, Unidad Saltillo, Saltillo, Coahuila, 25280, Mexico;2. Facultad de Ciencias Biológicas. Universidad Autonoma de Coahuila, Unidad Torreón, Torreón, Coahuila, 27000, Mexico;3. Facultad de Ingeniería Mecánica y Eléctrica. Universidad Autonoma de Coahuila, Unidad Torreón, Torreón, Coahuila, 27276, Mexico;1. Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida;2. Miami Veteran Affairs Hospital, Miami, Florida;1. Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, UK;2. Departments of Renal Medicine & Medicine, St. George Hospital & University of New South Wales, Sydney, Australia;3. Department of Obstetrics & Gynaecology, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa;4. Secretary General, World Organization Gestosis, Gupte Hospital, Pune, India;5. School of Medicine, Western Sydney University and South Western Sydney Local Health District, Sydney, Australia;6. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States;7. Faculty of Health & Life Sciences, University of Liverpool and INFANT Centre, Cork University Maternity Hospital, Cork, Ireland;8. Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland;9. Maternal & Fetal Health Research Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK;10. Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Chair of Hypertension in Pregnancy Subcommittee FIGO Pregnancy and NCD Committee, Hong Kong;11. Department of Obstetrics and Gynecology/Division of Maternal Fetal Medicine, University of Chicago, Chicago, IL, USA;12. Department of Obstetrics and Gynecology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Japan;13. Faculty of Medicine, University of Oslo, and Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway;14. Global Pregnancy Collaboration (Member, Steering and Executive Committees), USA;15. Preeclampsia Foundation, USA |
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| Abstract: | This study was conducted to test the hypothesis that acute, widespread N-nitro-l-arginine methyl ester (L-NAME) induced vasoconstriction and hypertension may affect glucose tolerance and insulin sensitivity in normal rats. Comparisons were made of blood pressure, intravenous glucose tolerance, and insulin response and 3H]-deoxyglucose tissue uptake between L-NAME and control treated rats.Chronically instrumented, awake rats were administered L-NAME (30 mg/kg) (n = 8) or saline (0.3 mL) (n = 8) intravenously. After blood pressure stabilized, a bolus injection containing glucose (300 mg/kg) and trace 3H]-deoxyglucose was administered. Arterial blood was sampled for evaluation of glucose tolerance, insulin response, and 3H]-deoxyglucose muscle uptake.L-NAME treated rats had a persistent 54 ± 4 mm Hg blood pressure rise while fasting, and postload plasma glucose and insulin responses did not differ, nor did heart and striated muscle 3H]-deoxyglucose uptake differ.In conclusion, acute L-NAME induced hypertension does not result in glucose intolerance, hyperinsulinemia, or decreased 3H]-deoxyglucose muscle uptake. |
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