| 棉酚诱发低血钾机制 |
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| 引用本文： | 王茂山,桑国卫.棉酚诱发低血钾机制[J].中国计划生育学杂志,2001,9(5):310-311. |
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| 作者姓名： | 王茂山 桑国卫 |
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| 作者单位： | 1. 浙江省医学科学院计划生育研究所,杭州,310013
2. 中国药品生物制品鉴定所,100050 |
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| 摘 要： | 棉酚已被认为是一种很有希望的男用抗生育剂,但它诱发的低血钾导致其不能进一步发展成为一种男用口服避孕药。棉酚诱发低血钾的机制虽已作了大量研究,但未被阐明。本文探讨并证明了棉酚及一些其它化合物对Ⅱ型11β-羟基甾体脱氢酶(11β-OHSD2)的抑制作用,并提出有关棉酚诱发低血钾机制的假说:棉酚抑制11β-OHSD2,引起肾脏中糖皮质激素的过量分泌,导致肾性失钾继而诱发低血钾。
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| 关 键 词： | 棉酚 诱发 低血钾 |
| 修稿时间： | 2001年8月20日 |
The Mechanism of Gossypol-induced Hypokalemia |
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| Wang Maoshan,Sang Guowei.The Mechanism of Gossypol-induced Hypokalemia[J].Chinese Journal of Family Planning,2001,9(5):310-311. |
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| Authors: | Wang Maoshan Sang Guowei |
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| Abstract: | Gossypol has been considered as a promising agent to induce infertility in many laboratory animals and in human kind, but the hypokalemia attributed to gossypol has inhibited further development of gossypot for use as a male oral contraceptive. The studies on the mechanism of hypokalemia induced by gossypol have not yielded a satisfac-tory explanation. We studied and proved the inhibition of type Ⅱ 11β-hydroxysteroid dehydrogenase (11 β-OHSD2)by gossypol and some other compounds,and our hypothesis remains that gossypol inhibits 11β-OHSH2 and causes gluco-corticoid excess in kidney ,leading to potassium lose and subsequent hypokalemia. |
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