宝藿甙-Ⅰ,Ⅵ,Ⅶ和宝藿素的分离和结构研究

自宝兴淫羊藿(Epimedium davidii Franch)中分离出8个黄酮类化合物,根据理化数据、光谱分析(UV,IR,¹HNMR,¹³CNMR,MS)和水解实验证明,其中E₃,E₁₃和E₈分别为已知成分淫羊藿甙、淫羊藿素和苜蓿素。E₁,E₁₁、E₁₆和E₁₅是新黄酮类化合物,并证明结构,分别命名为宝藿甙-Ⅰ(baohuoside Ⅰ),宝藿甙-Ⅵ(baohuoside Ⅵ),宝藿甙-Ⅶ(baohuo side Ⅶ)和宝藿素(baohuosu)。E¹⁷的结构待定。

Studies on the isolations and structures of baohuosides-I, VI, VII and baohuosu

Chemical studies of the herb Epimedium davidii Franch. have led to the isolation of a series of flavonoids including some new ones. This paper deals with the isolation of eight other flavonoid compounds-E₁, E₃, E₁₁, E₁₃, E₁₆, E₁₇, E₈ and E₁₅, and the structural determination of four new compounds as well as the identification of three known flavonoidglycosides. On the basis of spectroscopic analysis (UV, IR, MS, ¹HNMR and ¹³CNMR), acidic and enzymic hydrolysis, as well as the determination of their phyisical constants the structures of four new natural occurring compounds-E₁, E₁₁, E₁₆ and E₁₅ were elucidated as 3, 5, 7, -trihydroxy-4'-methoxyl-8-prenylflavone-3-O-α-L-rhamnopyranoside, 3, 5, 7-trihdroxy-4'-methoxyl-8-prenylflavone-3-O-α-L-rhamnopyranosyl (4←1)-α-L-rhamnopyranosyl-7-O-β-D-glucopyranoside, 3, 5, 7-trihydroxy-4'-methoxyl-8-prenylflavone 3-α-L-rhamnopyranosyl ( 4←1 ) -β-D-glucopyranoside and 5, 7, 4'-trihydroxy-3', 5'-dimethoxyl-8-prenylflavone and named as baohuoside-Ⅰ, baohuoside-Ⅵ, baohuoside-Ⅶ and baohuosu, respectively. The three other known flavonoids-E₃, E_(13) and E₈ were identified as icariin, icaritin and tricin. The full structure of the flavonoldiglycoside E_(17) is expected to be further determined. Tricin was discovered in the genus E pimedium for the first time.