| 肾母细胞瘤WT_1基因缺失 |
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| 引用本文： | 张卫星,宋东奎,高永亮,步星耀,李中凌,杨锦健,王瑞.肾母细胞瘤WT_1基因缺失[J].现代肿瘤医学,2000(4). |
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| 作者姓名： | 张卫星 宋东奎 高永亮 步星耀 李中凌 杨锦健 王瑞 |
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| 作者单位： | 河南医科大学第一附属医院泌尿外科!郑州45005(张卫星，宋东奎，步星耀，李中凌，杨锦健)，荥阳市人民医院外科!荥阳450100(高永亮)，河南医科大(王瑞) |
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| 摘 要： | 目的 对 30例散发性肾母细胞瘤WT1基因缺失进行检测 ,并分析其与组织类型的关系。方法 采用Southern印迹分子杂交技术。结果 2例WT1基因内缺失为间质优势型肾母细胞瘤。结论 肾母细胞瘤的病因学十分复杂 ,WT1基因缺失可能与间质优势型肾母细胞瘤的发生有关。
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| 关 键 词： | 肾母细胞瘤 基因 Southern印迹分子杂交技术 |
Deletion of WT_1 in wilms tumor. |
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| ZHANG Wei xing,SONG Dong kui,GAO Yong liang et al.Deletion of WT_1 in wilms tumor.[J].Journal of Modern Oncology,2000(4). |
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| Authors: | ZHANG Wei xing SONG Dong kui GAO Yong liang |
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| Institution: | ZHANG Wei xing,SONG Dong kui,GAO Yong liang et al. Department of Urology,the First Affiliated Hospital of Henan Medical University. Zhengzhou 450052,China |
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| Abstract: | Objective To study WT 1 gene from 30 cases of sporadic wilms tumor.Methods WT 1 gene was studied by Southern bolt hybridization with WT 1 cDNA probe.Results Two cases with intragenic deletions of WT 1 gene were histologically classified as stroma predominated wilms' tumor. Conclusion The etiology of wilms' tumor is complex, the deletion of WT 1 gene may be correlated with stroma predominated wilms tumor. |
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