The Efficacy and Safety of Neoadjuvant Chemotherapy in Treatment of Locally Advanced Carcinoma Cervix |
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Authors: | Uma Singh Neetu Ahirwar Anju Kumari Rani Nisha Singh Pushplata Sankhwar Sabuhi Qureshi |
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Affiliation: | 1. Department of Obstetrics & Gynecology, CSM Medical University, Lucknow, 226003, UP, India 2. Type IV/83, SGPGIMS, Raibareily Road, Lucknow, 226014, UP, India
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Abstract: | Objective A prospective cohort study in a teaching hospital to assess the efficacy and safety of neoadjuvant chemotherapy in the treatment of locally advanced carcinoma cervix. Method Neoadjuvant chemotherapy in the form of cisplatin 75 mg/m2 and paclitaxel 135 mg/m2 on day 1 and repeated at 14 days’ interval for up to a maximum of three courses. Results Neoadjuvant chemotherapy in cervical cancer was effective in the downstaging of the disease. Downstaging was observed in 19.23 % of patients after two cycles and in 50 % of patients after three cycle of NACT. Operability increases to 33.3 and 38.4 % after two and three cycles of NACT, respectively. Complete pathological response was observed in 37.5 % of patients after NACT. No significant adverse effect in the feasibility of surgery was observed. Conclusion The present study showed that neoadjuvant chemotherapy was an effective and well-tolerated mode of therapy with significantly less morbidity and mortality. |
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Keywords: | Cervical cancer Neoadjuvant chemotherapy Downstaging |
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