| 异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响 |
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| 引用本文： | 陈志远,王兴,李晓倩,王新勇,张卫国.异钩藤碱与天麻素合用对异钩藤碱在大鼠肝脏分布的影响[J].中国实验方剂学杂志,2012,18(20):193-196. |
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| 作者姓名： | 陈志远 王兴 李晓倩 王新勇 张卫国 |
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| 作者单位： | 西南交通大学生命科学与工程学院,成都,610031 |
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| 基金项目： | 国家自然科学基金项目(30801547);中央高校基本科研业务费专项资金项目(SWJTU11ZT26,SWJTU09ZT29) |
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| 摘 要： | 目的:观察天麻素与异钩藤碱合用前后异钩藤碱在SD大鼠肝脏的分布变化。方法:采用高效液相色谱法测定异钩藤碱与天麻素合用前后异钩藤碱在SD大鼠肝脏中的含量。色谱条件:WatersTM色谱柱(4.6 mm×250 mm,RP 18.5μm);流动相甲醇-水(70∶30),pH 8.0,流速0.8 mL.min-1,柱温30℃,检测波长254 nm,进样量20μL。结果:异钩藤碱对照品在肝脏组织中在0.16～4.0 mg.L-1具有较好的线性关系;异钩藤碱与天麻素配伍前后在肝脏中的分布无显著性差异。结论:天麻素有一定的降低异钩藤碱在肝脏分布的作用。
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| 关 键 词： | 钩藤 天麻 天麻素 异钩藤碱 |
| 收稿时间： | 2012/4/11 0:00:00 |
Distribution of Isorhynchophyline in Liver Tissures before and after Compatibility with Gastrodin and Isorhynchophylline in Rats |
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| CHEN Zhi-yuan,WANG Xing,LI Xiao-qian,WANG Xin-yong and ZHANG Wei-guo.Distribution of Isorhynchophyline in Liver Tissures before and after Compatibility with Gastrodin and Isorhynchophylline in Rats[J].China Journal of Experimental Traditional Medical Formulae,2012,18(20):193-196. |
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| Authors: | CHEN Zhi-yuan WANG Xing LI Xiao-qian WANG Xin-yong and ZHANG Wei-guo |
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| Institution: | School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China;School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | |
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| Keywords: | Uncariae Ramulus Cum Uncis Rhizoma Gastrodiae gastrodine isorhynchophylline |
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