Electron microscopic studies of herpes simplex virus type 1 infection of macrophages,T- and B-lymphocytes of mice |
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Authors: | Hanna Bruns |
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Affiliation: | (1) Institute for Medical Microbiology and Immunology, University of Bonn, Bonn, Germany |
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Abstract: | Summary The course of infection with herpes simplex virus type 1 (HSV-1) in peritoneal macrophages, phytohemagglutinin (PHA-)stimulated (T-)lymphocytes and lipopolysaccharide (LPS-)stimulated (B-)lymphocytes of NMRI-mice was studied by means of electron microscopy. Non-stimulated as well as thioglycolate-stimulated macrophages were investigated; lymphocytes were derived both from HSV-1-sensitized and non-sensitized animals. The morphological characteristics of the abortive infection in macrophages and T-lymphocytes and of the productive infection in B-lymphocytes are described. No differences were observed between stimulated and non-stimulated cells or cells of sensitized and non-sensitized animals.With 7 Figures |
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