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| 葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响 | |
| 引用本文： | 周军,方素萍,霍海如,齐云,郭淑英,姜廷良,施杞. 葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响[J]. 中国骨伤, 2002, 15(12): 724-726 |
| 作者姓名： | 周军 方素萍 霍海如 齐云 郭淑英 姜廷良 施杞 |
| 作者单位： | 1. 中国中医研究院中药研究所,北京,100700 2. 北京广安门医院分子生物室,北京 3. 上海中医药大学骨伤所,上海 |
| 基金项目： | 国家95攀登预选项目"中药现代化关键问题的基础研究"课题(970211018) |
| 摘 要： | 目的：观察葛根汤对模型大鼠退变颈椎间盘组织PGE2及COX活性的影响。以探讨葛根汤治疗颈椎病的抗炎作用机理。方法：选用动力失衡性颈椎病动物模型,造模后6个月,取出颈椎间盘组织,采用放免法,催化活性测定法分别测定PGE2含量及COX活性。结果：模型组PGE2含量及COX活性明显升高,葛根汤可下调PGE2的含量及抑制COX的活性。结论：葛根汤下调退变颈椎间透组织中PGE2的含量,与抑制COX活性密切相关,这可能是其治疗颈椎病的作用机制之一。 |
| 关 键 词： | 葛根汤 中草药 颈椎病 前列素E2 环氧合酶 治疗 |
| 收稿时间： | 2002-06-03 |
| 修稿时间： | 2002-06-03 |
Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats |
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| ZHOU Jun,FANG Su-ping,HUO Hai-ru. Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats[J]. China journal of orthopaedics and traumatology, 2002, 15(12): 724-726 | |
| Authors: | ZHOU Jun FANG Su-ping HUO Hai-ru |
| Affiliation: | Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China;Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
| Abstract: | Objective:To explore the anti-inflammation mechanism of GeGen Decoction (GGD) on cervical spondylosis by investigating GGD on Prostaglandin E2(PGE2) and Cyclooxygenase (COX) activity in degenerated cervical intervertebral discs Methods:Rats were modeled on the cervical dynamic unbalance, and 6 months later PGE2 content and COX activity in cervical intervertebral discs were measured by radioim-munoassay and catalytic activity assay, respectively. Results:The PGE2 and COX activity were significantly higher in experimental groups;GGD could down-regulate the content of PGE2 and inhabit COX activity. Conclusion:GGD could down-regulate the content of PGE2 activity in degenerated cervical intervertebral discs by inhabit COX activity, which may be one of its mechanisms in treating cervical spondylosis. |
| Keywords: | Chinese herbal drugs Cervical vertebrae disease Prostaglandin E2 Cyclooxygenase |
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