Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin |
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Authors: | T A Martin K Harding W G Jiang |
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Institution: | Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, UK. Martinta1@cf.ac.uk |
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Abstract: | BACKGROUND: Vascular endothelial cadherin (VE-cadherin/cadherin-5) has previously been described as playing a specific role in angiogenesis due to its localisation at areas of intercellular contact, where it functions in maintenance of tubular architecture. Matrix-bound fibroblasts have been show to produce a number of factors that are important in inducing angiogenesis and to promote tubule-formation by human endothelial cells, an indicator of angiogenic potential. RESULTS: Tubule formation stimulated by fibroblast-derived growth factors can be prevented by the addition of monoclonal antibody to VE-cadherin. In addition, fibroblasts-derived growth factors are able to modulate the expression and hence the regulation of this endothelial cell specific cadherin. CONCLUSIONS: The change in VE-cadherin expression of human endothelial cells by fibroblast-derived growth factors may contribute to the regulation of angiogenesis. |
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Keywords: | Angiogenesis endothelial cells matrix-bound fibroblasts VE-cadherin |
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