针刺治疗轻度认知功能障碍的系统评价

目的:系统评价针刺治疗轻度认知功能障碍的临床疗效及安全性,以期指导针刺治疗轻度认知功能障碍的临床实践。方法:采用循证医学的方法全面检索有关针刺治疗轻度认知功能障碍的文献161篇,并对所有的RCT文献进行方法学的质量评价。在此基础上利用Cochrane协作网提供的软件包RevMan5.0对符合Meta-分析纳入标准的14个RCT进行Meta-分析,同时进行异质性检验和敏感性分析,并用倒漏斗图分析潜在的发表性偏倚。结果:14个关于针刺治疗轻度认知功能障碍的随机对照试验共1052例病人纳入研究,合并OR值为2.89,95%可信区间CI[2.10,3.97],合并效应值检验Z=6.51,P0.00001,即针灸组与对照组的疗效差异有统计学意义。结论:本研究证明针刺治疗轻度认知功能障碍是安全有效的,但进一步研究需更多严格设计的、大样本、多中心随机对照试验支持。

Systematic review of acupuncture in treating mild cognitive impairment

Object Based on the principle of evidence - based medicine, the therapeutic effect and safety of acupuncture treatment for the mild cognitive impairment are systematically assessed. The Conclusion of this text would guide to the clinical practice. Methods The 161 essays which are about acupuncture treatment for the MCI are indexed by the evidence - based medicine method. All the RCT of the essays above are estimated and 14 of them which are consistent with the internalize standard are taken into the Meta - analysis which are performed by the Review Manager 5.0 statistical software. The sensitivity analyses and test for heterogeneity are taken at the same time. The publication bias are analysed by the funnel plot. Results 1052 patients in 14 RCT consistent with the internalize standard are taken into the Meta - analysis, OR = 2. 89, （95% CI, 2. 10 - 3.97 ）, test for overall effect Z = 6. 51, P 〈 0. 00001, indicating that there is statistical difference between the acupuncture group and the control group. Conclusion The acupuncture treatment for the MCI is effective and safe. However the conclusion is rather limited and it suggests that well - planned, large - scale and multi- pie -center, double -blinded, randomized controlled trials are required.