Isobolographic Analysis of the Interaction Between Tapentadol and Ketorolac in a Mouse Model of Visceral Pain |
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| Authors: | Juan R. Zapata‐Morales Othoniel H. Aragon‐Martinez Tely Adriana Soto‐Castro Ángel J. Alonso‐Castro Demian I. Castañeda‐Santana Mario A. Isiordia‐Espinoza |
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| Affiliation: | 1. Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, México;2. Facultad de Medicina, Departamento de Farmacología, Universidad Autónoma de San Luis Potosí, S.L.P., México;3. Facultad de Odontología, Departamento de Farmacología, Universidad Autónoma de Baja California, campus Mexicali, Mexicali, B.C., México;4. Departamento de Investigación, Centro de Educación Avanzada, Tepic, Nayarit, México |
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| Abstract: | The aim of this experimental assay was to assess the antinociceptive interaction between tapentadol and ketorolac in the acetic acid‐induced writhing model in mice. Tapentadol (5.62–31.6 mg/kg ip) or ketorolac (5.62–31.6 mg/kg ip) were administered 15 min before the acetic acid administration. The ED50 values of the individual drugs were determined and different proportions (tapentadol–ketorolac in 1:1, 3:1, and 1:3) were assayed in combination in the writhing test. Isobolographic analysis and the interaction index demonstrated an antinociceptive synergistic interaction between tapentadol and ketorolac in all combination. Thus, the experimental ED50 values were lower when compared with their theoretical ED50 values. These data suggest that the tapentadol–ketorolac combination produces an antinociceptive synergistic interaction in the mouse acetic acid‐induced writhing model. Drug Dev Res 77 : 187–191, 2016. © 2016 Wiley Periodicals, Inc. |
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| Keywords: | tapentadol ketorolac acute visceral pain test isobolographic analysis |
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