Two cases of primary non‐Hodgkin's lymphoma of female breast: Role of fine‐needle aspiration cytology and cell‐block immunohistochemistry

Primary breast lymphoma (PBL) is an uncommon neoplastic condition. Though HIV‐infection is a known risk factor for the development of extranodal lymphomas, mammary involvement is still a rarity. Radiologically, PBL appears as well circumscribed, heteroechoic, noncalcifying mass. Fine‐needle aspiration cytology (FNAC) is commonly used to diagnose this neoplasm; however, subcategorization requires immunophenotypic characterization of the neoplastic cells. Herein, we report two cases of PBL, including a HIV‐infected lady; in both the cases FNAC expressed features of non‐Hodgkin's lymphoma. Finally, immunohistochemistry on cell‐block with CD20 diagnosed both the cases as diffuse large B‐cell lymphoma (DLBCL). Diagn. Cytopathol. 2016;44:235–240. © 2015 Wiley Periodicals, Inc.