血清同型半胱氨酸检测在糖尿病肾病中的临床意义

目的探讨血清同型半胱氨酸检测在糖尿病肾病发生及发展中的临床价值。方法选择我院146例2型糖尿病患者,根据尿白蛋白排泄率和血肌酐水平分为单纯糖尿病组、早期糖尿病肾病组、临床糖尿病肾病组和肾衰竭组,30例健康体检者作为正常对照组,采用循环酶法分别检测其血清同型半胱氨酸水平并加以分析。结果各组血清同型半胱氨酸水平进行比较,糖尿病肾病组显著高于单纯糖尿病组,并且随着糖尿病患者肾脏损害程度的加重而升高,各组间比较差异均具有统计学意义(p<0.05)。结论高血清同型半胱氨酸水平与糖尿病患者肾脏损害程度相关,血清同型半胱氨酸水平有望作为糖尿病肾病的临床检测指标。

CLINICAL SIGNIFICANCE OF HOMOCYSTEINE DETERMINATION IN PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY

Objective To evaluate the clinical significance of serum homocysteine determination in patients with type 2 diabetic nephropathy. Methods 146 patients with type 2 diabetic were divided into normal proteinuria group(30 cases),microalbuminuria group(42 cases),clinical proteinuria group(42 cases) and chronic renal failure group(32 cases)according to 24 h urinary albumin excretion rate and serum creatinine.30 normal persons were chosen as normal control group.Then homoeysteine was detected with cyclophorase method.Results The serum levels of homocysteine in type 2 diabetic groups were obviously higher than that in normal control group,and the levels were heightened with the increment of albuminuria and renal function damage.Conclusion Homocysteine has relationship with diabetic nephropathy.And their levels were correlated with the degree of diabetic nephropathy.The levels of homocysteine can be used as the pathogenetic condition monitoring index of diabetic nephropathy.