慢性支气管炎动物模型的研究与进展

背景：近年来,许多学者纷纷通过构建和研究动物模型来模仿慢性支气管炎的病理特征,以进一步阐明其发病的遗传背景、诱发因素、发病机制。目的：对国内外诱导慢性支气管炎动物模型的现状及新进展作一综述。方法：应用计算机检索CNKI和Pubmed数据库中1999年1月至2011年10月关于慢性支气管炎动物模型的文章,在标题和摘要中以＂慢性支气管炎,动物,模型＂或＂chronic bronchitis,animals,model＂为检索词进行检索。最终选择24篇文献进行综述。结果与结论：建立慢性支气管炎动物模型的方法主要有化学药物法、细菌感染法、被动吸烟法和复合方法等,每种方法各有其优缺点,目前尚无一种公认最理想的方法,还有待于进一步的研究和探索。

Research progress in animal models of chronic bronchitis

BACKGROUND：In recent years,many scholars have done a lot of studies on pathological features of chronic bronchitis based on animal model construction to further elucidate the genetic background of the incidence,predisposing factors,and pathogenesis.OBJECTIVE：To summarize the investigative situation and progression about animal models of chronic bronchitis at home and abroad.METHODS：Databases of CNKI and PubMed（1999-01/2011-10）were searched to retrieve the related articles about animal models of chronic bronchitis using the key words of＂chronic bronchitis,animals,model＂ in Chinese and English,respectively.Finally,24 articles were included in result analysis.RESULTS AND CONCLUSION：The methods to construct an animal model of chronic bronchitis mainly include chemical medicine,bacterial infection,passive smoking and composite method.Each method has its own advantages and disadvantages.Up to now,there is no recognized ideal method that needs further studies.