| 阿霉素化疗与热化疗对兔毛细胞白血病VX-2细胞体外作用的比较 |
| |
| 引用本文： | 张洪新,王执民,郭卫平,王义清,吴智群,李文献,陈江浩,关燕.阿霉素化疗与热化疗对兔毛细胞白血病VX-2细胞体外作用的比较[J].癌症,1999,18(3):276-278. |
| |
| 作者姓名： | 张洪新 王执民 郭卫平 王义清 吴智群 李文献 陈江浩 关燕 |
| |
| 作者单位： | 第四军医大学唐都医院介入放射科,西安,710038 |
| |
| 摘 要： | 目的：观察比较热疗、化疗、热化疗对体外兔ＶＸ２细胞的生长抑制规律的影响，为临床介入性热化疗提供实验数据。方法：以体外长期培养的兔ＶＸ２细胞为靶细胞，采用水浴加温法、进行体外细胞毒试验（ＭＴＴ法），观察单纯热疗，单纯化疗及热疗与化疗结合对兔ＶＸ２细胞的生长抑制规律的影响及差别。结果：（１）温热和阿霉素对ＶＸ２均有一定的抑制和杀伤作用，两者一定方式的联合具有协同或相加作用；（２）热化疗加热温度以４２～４３℃为佳，加热时间以３０分钟以上为佳。结论：（１）热对化疗有增敏作用；（２）一定温度的热化疗优于单纯热疗和单纯化疗。
|
| 关 键 词： | 阿霉素 热化疗 |
Synergistic effect of combined use of hyperthermia and adriamycin (ADM) on rabbit hairy cell line VX-2 |
| |
| ZHANG Hongxin WANG Zhimin GUO Weiping,et al.Synergistic effect of combined use of hyperthermia and adriamycin (ADM) on rabbit hairy cell line VX-2[J].Chinese Journal of Cancer,1999,18(3):276-278. |
| |
| Authors: | ZHANG Hongxin WANG Zhimin GUO Weiping |
| |
| Institution: | ZHANG Hongxin WANG Zhimin GUO Weiping,et al Department of Interventional
Radiology,Tangdu Hospital,FourthMilitary Medical University,Xian 710038,China |
| |
| Abstract: | Objective: To observe the inhibition of cell growth of VX2 with MTT assay under waterheating
with ADM.Method:The hare leukemia VX2 cell line was used in this study.The inhibiton of cell
growth was observed with MTT assay under waterheating with ADM. Results: 1Both
hyperthermia and ADM can inhibit or kill the VX2 cells directly.The combination use of
hyperthermia and ADM shows evidence of synergistic or additional effect.2The optimal
temperature and time of hyperthermia are 4243 and 30 minutes. Conclusions:1Hyperthermia
enhanced the efficacy of chemotherapy,2Hyperthermia of definite temperature showed better
effect than those of heat or chemotherapy alone. |
| |
| Keywords: | VX-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
