| 影响原发性醛固酮增多症患者肾小球滤过率相关因素分析 |
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| 引用本文： | 曾健,李南方,王新玲,祖菲娅,张德莲,常桂娟,周克明.影响原发性醛固酮增多症患者肾小球滤过率相关因素分析[J].中华全科医师杂志,2012,11(2):141-143. |
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| 作者姓名： | 曾健 李南方 王新玲 祖菲娅 张德莲 常桂娟 周克明 |
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| 作者单位： | 新疆维吾尔自治区人民医院高血压中心新疆高血压研究所, 乌鲁木齐,830001 |
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| 基金项目： | 新疆维吾尔自治区科技成果转化专项资金项目 |
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| 摘 要： | 探讨原发性醛固酮增多症（PA）患者肾小球滤过率（GFR）状况及影响因素。选择PA患者156例，另选择原发性高血压（EH）患者189例作为对照，比较两组相关生化指标，估算肾小球滤过率（eGFR）等。PA组与EH组血清肌酐、eGFR、24h尿蛋白定量比较差异均有统计学意义（均P〈0．05）。多元回归分析结果显示PA患者血浆醛固酮浓度（P=0．003）及血清肌酐（P=0．001）与eGFR呈负相关，其eGFR低于EH患者；24h尿蛋白排泄率高于EH组患者。
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| 关 键 词： | 醛固酮增多症 肾小球滤过率 |
Risk factors of decreased glomerular filtration rate in patients with primary aldosteronism |
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| ZENG Jian
,
LI Nan-fang
,
WANG Xin-ling
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ZU Fei-ya
,
ZHANG De-lian
,
CHANG Gui-juan
,
ZHOU Ke-ming.Risk factors of decreased glomerular filtration rate in patients with primary aldosteronism[J].Chinese JOurnal of General Practitioners,2012,11(2):141-143. |
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| Authors: | ZENG Jian LI Nan-fang WANG Xin-ling ZU Fei-ya ZHANG De-lian CHANG Gui-juan ZHOU Ke-ming |
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| Institution: | . Xinjiang Institute of Hypertension, Diagnosis, Treatment and Research Center of Hypertension, People＇s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China |
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| Abstract: | One hundred and fifty-six patients with primary aldosteronism（PA） and 189 patients with essential hypertension （ EH ） were included in this study. The value of estimate glomerular filtration rate （eGFR） was calculated by MDRD equation. The plasma levels of aldosterone, triglycerides, creatinine and fasting glucose were measured. The plasma creatine, 24 hour urine albumin excretion in PA patients were higher and eGFR and plasma aldosterone were lower than those in EH patients （ all P 〈 0.01 ）. Multiple regression analysis revealed that the plasma concentrations of aldosterone （ P = 0. 003 ） and creatinine （ P = 0. 001 ） were independent predictors of eGFR. |
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| Keywords: | Hyperaldosteronism Glomerular filtration rate |
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