| 克山病病区粮喂养之大白鼠肝脏甲状腺素5′-脱单碘酶活性的改变 |
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| 引用本文： | 刘松岩,王凡.克山病病区粮喂养之大白鼠肝脏甲状腺素5′-脱单碘酶活性的改变[J].中国地方病学杂志,1989(5). |
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| 作者姓名： | 刘松岩 王凡 |
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| 作者单位： | 白求恩医科大学地方病研究所
(刘松岩)，白求恩医科大学地方病研究所(王凡) |
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| 摘 要： | 测定了以克山病病区粮和非病区粮喂养之大白鼠肝脏 T_4 5′-脱单碘酶活性和巯基含量。结果表明病区粮组动物肝脏 T_4 5′-脱单碘酶活性下降,其机制可能与低硒和巯基含量不足有关。提出肝脏损伤在克山病发病过程中可能起重要作用,值得深入研究。
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| 关 键 词： | 克山病 硒 T_4 5′-脱单碘酶 巯基 甲状腺激素 肝脏损伤 |
Change of hepatic deiodination of thyroxine(T4)in rats fed with grain from the endemic area of Keshan disease |
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| Liu Songyan Wang Fan.Change of hepatic deiodination of thyroxine(T4)in rats fed with grain from the endemic area of Keshan disease[J].Chinese Jouranl of Endemiology,1989(5). |
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| Authors: | Liu Songyan Wang Fan |
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| Institution: | Liu Songyan Wang Fan |
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| Abstract: | Hepatic thyroxine (T4) 5-monodeiodinase activity and sulfhydryl groupscontent were respectively determined in rats fed with grain from Keshan diseasearea and non-endemic area.The results indicated that the ability of conversionof T4 to triiodothyronine (T3) in the livers of the rats fed with grain fromendemic area of Keshan disease was decreased.The mechanism may involve sele-nium deficiency and insufficient sulfhydryl in the animal body.It is suggestedthat liver injury may play an important role in occurrance of Keshan disease. |
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| Keywords: | Keshan disease T4 5-monodeiodinase Selenium Sulfhydryl Thyroid hormones Liver injury |
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