| 肝硬变门静脉高压症患者肝组织中组胺H1和H2受体变化的研究 |
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| 作者姓名： | Zhang Z Leng X Feng H Ma F Wang B |
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| 作者单位： | 解放军二五二医院普通外科,北京医科大学人民医院外科,解放军石家庄医学高等专科学校外科教研室 |
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| 摘 要： | 目的研究肝硬变门静脉高压症患者肝组织组胺Ｈ１和Ｈ２受体的变化。方法光学放射自显影术。结果Ｈ２受体密度在肝硬变患者肝细胞１６８４±２２６显著低于对照组５１１９±３７６（Ｐ＜００１）;肝静脉２３８８±４０７显著低于对照组３１３０±５２４（Ｐ＜００１）;肝动脉５５６±７１显著低于对照组１７５４±２６１（Ｐ＜００１）;门静脉５２０±５４显著低于对照组１６６４±１７７（Ｐ＜００１）;肝硬变患者Ｈ１受体密度在肝细胞、肝静脉、肝动脉和门静脉与对照组相比差异均无显著性意义（Ｐ＞００５）。结论肝硬变门静脉高压症患者肝细胞及肝内各血管壁的Ｈ２受体显著降低
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| 关 键 词： | 肝硬化 受体.组胺 放射自显影术 |
Histamine-1 and -2 receptors in hepatic tissues of cirrhotic patients with portal hypertension |
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| Zhang Z,Leng X,Feng H,Ma F,Wang B.Histamine-1 and -2 receptors in hepatic tissues of cirrhotic patients with portal hypertension[J].Chinese Journal of Surgery,1998,36(6):348-349. |
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| Authors: | Zhang Z Leng X Feng H Ma F Wang B |
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| Institution: | Department of General Surgery, 252nd Hospital of People's Liberation Army, Baoding 071000. |
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| Abstract: | OBJECTIVE: To study histamine-1 and histamine-2 receptors in hepatic tissues of cirrhotic patients with portal hypertension. METHOD: Light autoradiography was used. RESULT: The density of histamine-2 (H-2) receptors (cirrhotic patients/controls) in hepatocytes was 168.4 +/- 22.6/511.9 +/- 37.6 (P < 0.01), in hepatic vein 238.8 +/- 40.7/313.0 +/- 52.4 (P < 0.01), in hepatic artery 55.6 +/- 7.1/175.4 +/- 26.1 (P < 0.01), and in portal vein 52.0 +/- 5.4/166.4 +/- 17.7 (P < 0.01). The density of histamine-1 receptors in hepatocytes, hepatic vein, hepatic artery and portal vein was not statistically changed between cirrhotic patients and controls (P > 0.05). CONCLUSION: The density of H-2 receptors in hepatic tissues of cirrhotic patients decreased significantly. |
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| Keywords: | Liver cirrhosis Receptors histamine Autoradiography |
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