国产机械可脱式弹簧圈介入治疗的动物试验及临床应用

目的 通过国产机械可脱式弹簧圈（ＭＤＳ）的动物试验及临床初步应用,观察其操作性能及致血凝性。方法 利用中国白兔建立分叉部位动脉瘤模型,２周后进行国产机械可脱式弹簧圈的栓塞。５个动脉瘤共使用弹簧圈２４枚。２￣３周后造影复查,并处死动物,滠出动脉瘤标本进行病理检查。临床应用于１０例患者的栓塞,其中动脉瘤７例,外伤性颈内动脉海绵窦瘘（ＣＣＦ）２例,海锦窦区硬脑膜动静脉瘘（ＤＡＶＦ）１例。共使用弹簧圈１４

Animal experiment and clinical application of self-made mechanically detachable coils

OBJECTIVE: To evaluate the practical and thrombogenetic characteristics of self-made mechanically detachable coils by the animal experiment and primary clinical application. METHOD: The bifurcation type of aneurysm model was established on rabbit and embolized with self-made mechanically detachable coils 2 weeks after surgery. 24 coils were used in 5 experimental aneurysms. Control angiography was performed and the rabbits were sacrificed 2 - 3 weeks after the embolization. The embolized aneurysm samples were examined by pathologist. Ten patients were treated with self-made mechanically detachable coils in primary clinical application. They were divided into aneurysms (7 patients), traumatic carotid-carvenous fistulas (2), dural arterio-venous fistula in carvenous sinus region (1). 146 coils were used totally and all were delivered with mechanical detachable system (MDS Balt co. France). RESULT: Pathologically, the cavities of rabbit aneurysm models were occluded by tungsten coils (2 complete, 3 almost complete). The coils were trapped in granulation tissue which was covered by a thin layer of endothelium on the surface facing the blood flow. In the coils dense packing ones, the aneurysms were completely excluded from the parent circulation by neointimal layers. In the practice procedures, the coils fit MDS (Balt co. France) very well and can be delivered, withdrew and detached smoothly. CONCLUSION: The self-made mechanically detachable coils have practical reliability and evident thrombogenetic effects.