外伤性假性动脉瘤动物模型的建立及实验研究

目的模拟临床所见动脉损伤破裂，建立假性动脉瘤动物模型，研究其形成过程与机理；并对彩超、ＣＴ、ＭＲＩ、动脉造影诊断假性动脉瘤的价值进行比较研究。方法采用创伤法及显微外科技术，在５４只兔７２条股动脉制作假性动脉瘤实验模型。结果６９个模型成功，成功率为９５．８％。结论通过实验和临床分析，提出了预测假性动脉瘤破裂大出血的临床指征；建立了球囊扩张导管暂时阻断载瘤动脉血流的有效控制术中出血的方法。

Setting up animal model of traumatic pseudoaneurysm: experimentsal and clinical study

OBJECTIVE: To patlern the clinical ruptures of injured arteries. METHODS: Traumatic methods and microsurgery were employed. RESULTS: Experimental model of pseudoaneurysm was made in 72 femoral arteries of 54 Japanese white rabbits, with a successful rate of 95.8%. Using these models, the process and the mechanism for the formation of pseudoaneurysm were studied. The effects of color Doppler's ultrasonic image, CT, MRI and arterial angiography in the diagnosis of pseudoaneurysm were evaluated. CONCLUSION: The indicators for clinical signs of the rupture hemorrhage of pseudoaneurysm were put forward. The methods for balloon dilation to block the blood supply of the carrier artery and control the hemorrhage of operation were set up.