| 大鼠肝小肠联合移植肠壁酶活性变化的研究 |
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| 作者姓名： | Wang G Sun X Wei M Shi H Ru L |
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| 作者单位： | 同济医科大学同济医院小儿外科,同济医科大学神经生物教研室 |
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| 摘 要： | 目的探讨肝小肠联合移植后肠壁酶活性的变化及其与移植肠功能和免疫排斥反应之间的关系。方法用封闭群大鼠建立肝小肠联合移植模型,术后定期对移植组织进行病理学、酶组织化学检查。结果单独小肠移植组术后均发生排斥反应,肠壁酶活性消失。肝小肠联合移植组５６％可避免排斥反应,肠壁酶活性和神经成分得以保持和恢复。结论肝小肠联合移植可使供肠避免或推迟被排斥。术后检测肠壁酶活性和神经成分的变化可用于监测排斥反应
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| 关 键 词： | 器官移植 小肠移植 酶 |
The enzymes activity of intestine grafts after combined small bowel/liver transplantation in rats |
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| Wang G,Sun X,Wei M,Shi H,Ru L.The enzymes activity of intestine grafts after combined small bowel/liver transplantation in rats[J].Chinese Journal of Surgery,1998,36(6):376-378. |
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| Authors: | Wang G Sun X Wei M Shi H Ru L |
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| Institution: | Department of Pediatric Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030. |
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| Abstract: | Objective To study the alteration of the enzymes activity of intestine grafts after combined small bowel/liver transplantation in rats and the relations between their changes, functions and immune rejection. Method A kind of model of combined small bowel/liver transplantation (SLT) was established in SD closed colony rats. The enzymes activity of grafts were examined at regular postoperative intervals with histochemical methods. Result The enzymes activity of grafts disappeared eventually in isolated small bowel transplanation rats.Contrary,those in SLT rats were remained and recovered after operation. Conclusion The rejection in grafted intestine can be prevented or delayed in SLT rats. The examination of activity of enzymes and nerves in grafts may be used to monitor rejection and study function of grafts. |
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| Keywords: | Organ transplantation Small bowel transplantation Enzyme |
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