p63和CK5/6在肺癌组织中的表达及临床意义

目的探讨p63蛋白和CK5/6在肺癌组织中的表达及其与临床病理的关系。方法应用免疫组化SP法分别检测106例肺癌组织中p63和CK5/6蛋白质的表达并对结果进行分析。结果 p63在肺癌中阳性表达率为54.72%(58/106),其中在肺鳞癌中的阳性表达率(84.09%)明显高于在腺癌中的(23.26%)(P<0.05);CK5/6在肺癌中阳性表达率为43.40%(46/106),其中CK5/6在肺鳞癌中的阳性表达率(77.27%)明显高于在腺癌中的(9.30%)(P<0.05)。在不同年龄、不同分化程度、不同临床分期以及有无淋巴结转移的肺癌患者中,p63和CK5/6阳性表达率均无显著性差异(P>0.05)。肺癌组织中p63表达与CK5/6表达呈正相关(rs=0.628,P=0.01)。结论 p63、CK5/6的表达与肺癌病理类型密切相关,二者在肺癌中的表达密切相关。

Expression and clinical significance of p63 and CK5/6 in lung cancer

Objective To detect the expression of p63 and CK5/6 in lung cancer and to evaluate their clinical significance. Methods The expression of p63 and CK5/6 from 106 lung cancer tissue specimens were detected by immunohistochemical S-P method, together with their clinicopathologic data. Results The positive rate p63 protein in lung cancer was 54.72%（58/106）. The positive rate of p63 protein in squamous cell lung cancinoma（84.09%） was higher than that in adenocarcinoma（23.26%）（P〈0.05）. The positive rate CK5/6 protein in lung cancer was 43.40%（46/106）. the positive rate of CK5/6 protein in squamous cell lung cancinoma（77.27%） was higher than that in adenocarcinoma（9.30%）（P〈0.05）. The expression of p63 and CK5/6 protein was negatively correlated with age, lymph node metastasis, degree of differentiation and clinical staging of lung cancer（P〉0.05）. and the expression of p63 and CK5/6 protein was correlated with the expression of CK5/6 protein（rs=0.628, P=0.01）. Conclusion p63 and CK5/6 may be a useful panel for the identification and differential of lung cancer.