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| 贲门癌高发区慢性萎缩性贲门炎患者血清蛋白质质谱的变化 | |
| 引用本文： | 王道存,王立东,郑树,范宗民,李吉林,冯常炜,张延瑞,刘宾,郭涛,高珊珊,何欣,王俊宽,刘小莉,江亚南,王能超,王苒,孙哲,焦新英.贲门癌高发区慢性萎缩性贲门炎患者血清蛋白质质谱的变化[J].郑州大学学报(医学版),2006,41(1):39-41. |
| 作者姓名： | 王道存 王立东 郑树 范宗民 李吉林 冯常炜 张延瑞 刘宾 郭涛 高珊珊 何欣 王俊宽 刘小莉 江亚南 王能超 王苒 孙哲 焦新英 |
| 作者单位： | 1. 郑州大学医学实验中心癌症研究室,河南省食管癌重点开放实验室,郑州大学第一附属医院内科,郑州,450052 2. 浙江大学肿瘤研究所,杭州,310009 3. 林州市姚村食管癌医院病理科,林州,456592 4. 郑州大学第二附属医院消化内科,郑州,450014 5. 河南省人民医院消化内科,郑州,450003 6. 首都医科大学同仁医院消化内科,北京,100730 |
| 基金项目： | 国家重点基础研究发展计划(973计划) , 河南省高校创新人才培养项目 , 河南省医学科技攻关项目 , 河南省食管癌开放实验室基金 , 郑州大学校科研和教改项目 |
| 摘 要： | 目的:检测贲门癌高发区人群慢性萎缩性贲门炎(CAG)患者血清蛋白质质谱变化.方法:采用弱阳离子结合芯片(WCx2)及表面加强激光解吸/电离飞行时间质谱仪(SELDI-TOF-MS)对食管癌高发区普查人群中活检组织诊断为正常的63人和CAG的57人的血清蛋白质质谱进行检测,找出差异蛋白质.结果:2组间有165种质核比在2 010～49 170的蛋白质谱图被标记,其中CAG人群中升高37种,降低31种(P＜0.05).结论:CAG人群存在多种血清蛋白质的变化. |
| 关 键 词： | 贲门癌高发区 慢性萎缩性贲门炎 蛋白质质谱 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005年9月12日 |
Changes of serum proteomic image of chronic atrophic gastric-carditis from high risk population of gastric-cardia adenocarcinoma |
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| WANG Daocun,WANG Lidong,ZHENG Shu,FAN Zongmin,LI Jilin,FENG Changwei,ZHANG Yanrui,LIU Bin,GUO Tao,GAO Shanshan,HE Xin,WANG Junkuan,LIU Xiaoli,JIANG Yanan,WANG Nengchao,WANG Ran,SUN Zhe,JIAO Xinying.Changes of serum proteomic image of chronic atrophic gastric-carditis from high risk population of gastric-cardia adenocarcinoma[J].Journal of Zhengzhou University: Med Sci,2006,41(1):39-41. | |
| Authors: | WANG Daocun WANG Lidong ZHENG Shu FAN Zongmin LI Jilin FENG Changwei ZHANG Yanrui LIU Bin GUO Tao GAO Shanshan HE Xin WANG Junkuan LIU Xiaoli JIANG Yanan WANG Nengchao WANG Ran SUN Zhe JIAO Xinying |
| Abstract: | Aim: To determine the changes of serum proteomic image of chronic atrophic gastric-carditis subjects (CAG) from high risk population for gastric cardia adenocarcinoma (GCA). Methods: Proteomic spectra were generated by surface-enhanced laser desorption/inionation-time of flight-mass spectra (SELDI-TOF-MS) and weak cation exchange (WCX2) proteinchip system. A set of spectra derived from analysis of serum from 120 symptom-free subjects at high-risk area for GCA, including 63 cases of histologically normal gastric cardia epithelia and 57 cases of CAG, were analyzed by peak detection and alignment with a Biomarker Wizard Microsoft. Results: A total of 165 qualified mass peaks with mass to charge ratios (M/Z) between 2 010 and 49 170 were detected,37 peaks in CAG subjects were significantly higher,and 31 were lower than those in normal subjects(P<0.05). Conclusion: Different patterns of serum protein changes in the subjects with CAG have been detected using SELDI-TOF-MS technique, which provides a desirable basis to establish the novel protein file for identifying the subjects with CAG. |
| Keywords: | high-incidence area for gastric cardia adenocarcinoma chronic atrophic gastric-carditis proteomic image |
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