| 麦芽醇对大鼠局灶性脑缺血再灌注损伤后神经元凋亡的影响 |
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| 引用本文： | 高艳,戴冀斌,李应续. 麦芽醇对大鼠局灶性脑缺血再灌注损伤后神经元凋亡的影响[J]. 咸宁医学院学报, 2007, 21(1): 4-6 |
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| 作者姓名： | 高艳 戴冀斌 李应续 |
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| 作者单位： | [1]武汉大学基础医学院,湖北武汉430071 [2]武汉大学医学部解剖学教研室,湖北武汉430071 [3]咸宁学院医学院解剖学教研室,湖北武汉430071 |
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| 摘 要： | 目的观察麦芽醇对大鼠局灶性脑缺血再灌注损伤后海马神经元内Caspase-3和神经元凋亡的影响。方法大脑中动脉线栓法建立脑缺血再灌注损伤模型,应用免疫印迹法和流式细胞计数法分别检测Caspase-3和细胞凋亡。结果再灌注72h后海马Caspase-3表达升高,凋亡细胞增多,麦芽醇组Caspase-3表达和凋亡细胞明显减少。结论麦芽醇对脑缺血再灌注损伤有保护作用。
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| 关 键 词： | 麦芽醇 脑缺血 凋亡 |
| 文章编号： | 1008-0635(2007)01-0004-03 |
| 修稿时间： | 2006-09-12 |
The Effects of Maltol on Neuronal Apoptosis after Focal Cerebral Ischemia-reperfusion in Rats |
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| GAO Yan,DAI Ji-bin,LI Ying-xu. The Effects of Maltol on Neuronal Apoptosis after Focal Cerebral Ischemia-reperfusion in Rats[J]. Journal of Xianning Medical College, 2007, 21(1): 4-6 |
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| Authors: | GAO Yan DAI Ji-bin LI Ying-xu |
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| Affiliation: | Fundamental Medical College of Wuhan University, Wuhan Hubei 430071, China |
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| Abstract: | Objective To investigate the effects of maltol on expression of Caspase-3 protein in neurons and neuronal apoptosis after focal cerebral ischemia-reperfusion in rats.Methods A model of middle cerebral artery occlusion(MCAO)in rats was established with intraluminal filament occlusion.The Western-blot and flowcytomete were used respectively to observe the quantities of Caspase-3 protein and neuronal apoptosis in hippocampus.Results A significant increase in Caspase-3 immunoreactivity and apoptosis were detected at 72h after reperfusion.The difference of Caspase-3 and apoptosis between ischemic group and maltol group were significant.Conclusion Maltol can protect cerebral tissues by inhibiting cell apoptosis in ischemia reperfusin damages. |
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| Keywords: | Maltol Cerebral ischemia Apoptosis |
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