河南食管癌高发区ABO血型及血细胞分类记数与食管和贲门癌关系研究

目的 :通过分析河南辉县食管癌高发区食管癌和贲门癌患者ABO血型分布以及全血细胞的变化特征 ,进一步了解这些变化与食管和贲门癌的关系。方法 :统计辉县市人民医院 17年间 (1987～ 2 0 0 3 )食管和贲门癌收治记录 ,分析比较食管和贲门癌患者各血型的分布情况以及各种血细胞数量的差异。结果 :食管癌患者中 ,男女均为B型血比例最高 ,分别占 3 8. 6%和 3 4. 7% ;贲门癌男性患者中 ,O型血所占比例最高(3 9 .6% ) ;贲门癌女性患者中 ,B型血 (4 6. 7% )所占比例远高于其它血型 ;而AB血型的人在食管和贲门癌中所占的比例都最低 (7. 7%V S 13 .2 % )。食管癌及贲门癌患者均出现不同程度的全血细胞降低改变 ,贲门癌患者红细胞降低最明显 (男 :5 0 % ,女 :5 6% ) ,类似的情况还见于血红蛋白。贲门癌患者淋巴细胞降低的检出率高于食管癌患者。贲门癌患者贫血和淋巴细胞降低明显 ,其临床意义尚待进一步研究。结论 :B型血患食管癌的风险较大 ,O型血的男性和B型血的女性患贲门癌的风险较大 ,而AB型患食管和贲门癌的风险均较低。而外周血各项常规指标的变化与食管和贲门癌的关系还有待于进一步研究。

Relationship of ABO blood type and blood cell classification with esophageal and gastric cardia cancers in Henen province, the high incidence area for esophageal and gastric cardia cancers

Objective: To characterize the patterns of ABO blood type and alteration of whole blood analysis in esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) from the patients in high incidence area for SCC and GCA in Huixian, HenanMethods: All the SCC and GCA patients were enrolled from Huixian People's Hospital from 1987 to 2003 Blood type and blood cell alteration were recorded and correlated with SCC and GCAResults: In SCC,B blood type was the main pattern for both male and female (39% and 35%)In GCA,however, O blood type was more frequently observed in male (40%), B blood type was the main type in female (47%) The decreasing with different degrees of blood cells was observed both in SCC and GCA, especially in GCA with a decreasing rate of red blood cell with 50% in male and 56% in female The similar pattern was observed in hemoglobin The decreasing rate of lymph cells was more apparent in SCC than that in GCAConclusion: The present results indicate that SCC occurs more frequently in patients with B blood type, GCA seems to occur more frequently in male with O blood type and B blood type in femaleAnemia and lymph cell decreasing are very common in GCA, and its clinical significance needs to be further characterized