自制支气管封堵器介入性肺叶切除实验研究

目的:探讨运用自制支气管封堵器行介入性肺叶切除的可行性.方法::健康犬12只随机分成3组,每组4只,A、B 组行靶肺支气管肺泡灌注平阳霉素-碘化油乳剂,A组用支气管封堵器堵塞靶支气管,B组用骨水泥堵塞靶支气管,C组为空白对照组.分别于术后28d及56d取肺组织,测定肺纤维化的程度.结果:A、B组动物均示肺不张形成,组织病理学显示靶肺呈纤维化改变;A、B组非靶肺与C组双肺均未见明显纤维化.结论:通过支气管肺泡灌注平阳霉素-碘化油乳剂后堵塞靶支气管可达到介入性肺叶切除目的,其中使用国产支气管封堵器比骨水泥行介入性肺叶切除术更方便,是一种安全简便的方法.

Experiment Study of Self-made Bronchial Occlusive Equipment for Interventional Pulmonary Lobectomy in Dogs

Objective:To study the feasibility of interventional pulmonary lobectomy (IPLT) in dogs used self-made bronchial-occlusive equipment.Methods:12 healthy dogs were divided into three groups randomly (n=4 for each).In group A and B,pingyangmycin and lipoidal emulsion (PLE) was injected into the target lung via bronchial catheter.Bronchial occlusive equipment in Group A and polymethylmethacrylate (PMMA) in Group B was used to obstruct the target bronchus.Group C was the control group.The experimental animals were sacrificed on the 28th and 56th day respectively,the lung tissue was sent for pathological examination.The degree of pulmonary fibrosis were measured under microscope.Results:Atelectasis and pulmonary fibrosis were revealed in the target lung both in Group A and B.Pulmonary fibrosis was not found in non-target lung of Group A and B as well as group C.Conclusion:IPLT could be obtained after injection of PLE into the target lung in combination with occlusion of the target bronchus.Using self-made bronchial occlusive equipment was a safe and efficient approach for IPLT,which was more convenient than using PMMA.