氟、砷及氟砷联合作用对小鼠肝、脑、肾氧化损伤的实验研究

目的　探讨氟、砷及氟砷联合作用对肝、脑、肾损害的机理。方法　用高氟、高砷、高氟高砷饲料分别饲养小鼠 12mo ,分别检测肝、脑、肾的LPO和GSH含量和SOD及GSH Px活性。结果　与对照组比较 ,氟组、砷组及氟砷联合组GSH含量均显著降低 ;各组SOD活力显著降低 ;除脑组织GSH PX降低不明显外 ,其余各组均显著降低。结论　氟、砷及氟砷联合作用均可使小鼠肝、脑、肾LPO增强 ,抗氧化能力降低 ,而且发现氟砷联合拮抗作用并不明显。

Experimental study on the Peroxidation injuries of Fluoride 、Arsenic、combination of Fluoride-arsenic Effects on liver 、kidney、brain in mice

Objective To explore the mechanism of kidney, liver, brain effects caused by Fluoride, Arsenic and Fluoride Arsenic in mouse.Methods The mice were fed with four different diets supplemented respectively with Fluoride, Arsenic and Fluoride arsenic for 12 months. The contents of LPO, GSH and the activities of liver SOD, GSH PX in liver ,brain and kidney were determined.Results Compard with control group, the contents of GSH in Fluoride group?Arsenic group and Fluoride Arsenic group were significantly decreased; The activity of SOD in all groups were markedly decreased; Except for brain, the activity of GSH PX in all groups were significantly reduced.Conclusions Fluoride, Arsenic, Flouride arsenic could increase the lever of LPO of in mice liver, kidney and brain, meanwhile the antagonistic effects between Fluoride and Arsenic was not observed.