No association between DCP1 genotype and late‐onset Alzheimer disease |
| |
| Authors: | Svenja Buss Tomas Müller‐Thomsen Cristoph Hock Antonella Alberici Giuliano Binetti Roger M. Nitsch Andreas Gal Ulrich Finckh |
| |
| Affiliation: | 1. Department of Human Genetics, University Hospital Hamburg‐Eppendorf, University of Hamburg, Hamburg, Germany;2. Psychiatry, University Hospital Hamburg‐Eppendorf, University of Hamburg, Hamburg, Germany;3. Division of Psychiatry Research, University of Zürich, Zürich, Switzerland;4. Scientific Institute for Research and Patient Care, S. Giovanni di Dio, Brescia, Italy |
| |
| Abstract: | In a study of 261 patients with Alzheimer disease (AD) and 306 cognitively normal control subjects from Germany, Switzerland, and Italy, we found no association between genotype counts or allelic frequencies of DCP1, the gene encoding angiotensin‐converting enzyme. In accordance with several other studies, our data could not confirm previous association findings. Critical review about all studies available on DCP1 genotyping and AD, age‐associated cognitive decline, longevity, and other conditions revealed remarkable inconsistencies. Several studies showed significant deviations of genotype counts from Hardy Weinberg equilibrium (HWE). Deviations from HWE may limit the comparability of study results and require clarification before drawing conclusions with respect to disease risk, health conditions, or longevity in association with DCP1 genotype. © 2002 Wiley‐Liss, Inc. |
| |
| Keywords: | ACE DCP1 Hardy Weinberg equilibrium HWE review |
|
|
