Greenberg dysplasia (hydrops–ectopic calcification–moth‐eaten skeletal dysplasia): Prenatal ultrasound diagnosis and review of literature |
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Authors: | Zoran Trajkovski Miodrag Vrcakovski Jordan Saveski Zoran S. Gucev |
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Affiliation: | 1. Institute of Radiology, Medical Faculty Skopje, Skopje, Macedonia;2. Trauma Clinic, Medical Faculty Skopje, Skopje, Macedonia |
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Abstract: | A second pregnancy of young, nonconsanguineous parents of Macedonian ethnic origin was examined by ultrasound. Polyhydramnios and hydrops fetalis were found as well as severe short limb, short stature, and cystic hygroma of the neck. An artificial abortion was performed at the age of 23 weeks. The radiological features included moth‐eaten severely shortened long bones and ectopic calcifications of long bones, vertebral column, ribs, pelvis, larynx, trachea. In addition, the fetus had large head with depressed nasal bridge, severe platyspondyly, and short barrel‐shaped trunk. Light microscopy demonstrated lack of chondrocyte columns and disorganization of the cartilaginous architecture. This is the seventh reported case of this rare form of lethal skeletal dysplasia. © 2002 Wiley‐Liss, Inc. |
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Keywords: | Greenberg dysplasia short limbed short stature moth eaten ectopic calcification cystic hygroma fetal lethal |
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