| 依据CT总碘摄取量预测胃癌新辅助化疗的反应 |
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| 引用本文： | 张阳,张欢,丁蓓,袁菲,马乾辰,王柏松,严福华,杜联军.依据CT总碘摄取量预测胃癌新辅助化疗的反应[J].外科理论与实践,2019(1):33-39. |
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| 作者姓名： | 张阳 张欢 丁蓓 袁菲 马乾辰 王柏松 严福华 杜联军 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院放射科;上海交通大学医学院附属瑞金医院病理科;上海交通大学医学院生物统计学教研室 |
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| 基金项目： | 国家自然科学基金(81771789;U1532107);上海市科学技术委员会项目(18411953000) |
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| 摘 要： | 目的:前瞻性评估双能量CT(dual-energy computed tomography, DECT)中的总碘摄取(total iodine uptake,TIU)在预测胃癌病人新辅助化疗疗效和无进展生存期(progression-free survival, PFS)的应用价值。方法:收集我院44例化疗前、后均行DECT扫描的局部进展期胃癌病人。计算肿瘤面积(%ΔS),直径(%ΔD)和密度(%ΔHU)的变化率来评估WHO、RESCIST和Choi标准。同时计算肿瘤体积(%ΔV)和门静脉期TIU的变化率(%ΔTIU-p)来评估ROC曲线下的界值。统计学分析不同标准与组织病理退缩分级(Becker)或PFS间的关系。结果:分别根据ΔV(43.34%,P=0.002)和ΔTIU-p(63.87%,P=0.002)的界值将病人分为反应组和非反应组。%ΔTIU-p标准与Becker间显示较强的相关性(r=0.602,P<0.001),%ΔV显示中等相关(r=0.416, P=0.005),而WHO(r=0.075, P=0.627), RECIST(r=0.270, P=0.077)和Choi标准(r=0.238, P=0.120)与Becker间无相关性。%ΔTIU-p(P=0.001)和Choi标准(P=0.013)的反应组和非反应组PFS间差异具有统计学意义。结论:TIU-p可预测进展期胃癌病人新辅助化疗后病理退缩。%ΔTIU-p分析新辅助化疗后的PFS有一定意义。
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| 关 键 词： | 胃癌 新辅助化疗 总碘摄取量 病理退缩 无进展生存期 |
Total iodine uptake in CT for predicting results of neoadjuvant chemotherapy in gastric cancer |
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| ZHANG Yang,ZHANG Huan,DING Bei,YUAN Fei,MA Qianchen,WA NG Baisong,YAN Fuhua,DU Lianjun.Total iodine uptake in CT for predicting results of neoadjuvant chemotherapy in gastric cancer[J].Journal of Surgery Concepts & Practice,2019(1):33-39. |
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| Authors: | ZHANG Yang ZHANG Huan DING Bei YUAN Fei MA Qianchen WA NG Baisong YAN Fuhua DU Lianjun |
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| Institution: | (Department of Radiology,Ruijiri Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China;Department of Pathology, Ruijiri Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China;Department of Biological Statistics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) |
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| Abstract: | ZHANG Yang;ZHANG Huan;DING Bei;YUAN Fei;MA Qianchen;WA NG Baisong;YAN Fuhua;DU Lianjun(Department of Radiology,Ruijiri Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China;Department of Pathology, Ruijiri Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China;Department of Biological Statistics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) |
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| Keywords: | Gastric cancer Neoadjuvant chemotherapy: Total iodine uptake Pathologic regression Progression-free survival |
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