10661例体检者幽门螺杆菌感染情况及其相关危险因素分析

目的了解健康体检人群幽门螺杆菌感染情况及相关危险因素分析。方法对2019年1月1日至2020年12月30日在川北医学院附属医院行碳13/尿素呼气试验(¹³C-UBT)的10 661例健康体检人群作为研究对象进行回顾性分析。根据幽门螺杆菌（H.pylori）感染情况将受检者分为H.pylori阳性组和H.pylori阴性组,分析H.pylori感染与血小板（PLT）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、T3、T4、TSH、胃蛋白酶原Ⅰ（pepsinogenⅠ）、胃蛋白酶原Ⅱ（pepsinogenⅡ）、胃泌素17（G-17）、同型半胱氨酸（Hcy）、尿酸（UA）、总胆红素（TBIL）之间的关系。结果 1)阳性感染总人数:4 382例,总阳性率:41.10%,其中男性阳性感染人数2 717例,阳性率25.49%;女性阳性感染人数1 665例,阳性率15.62%,男性高于女性（P<0.05）;2)H.pylori阳性组和阴性组相比:阳性组年龄稍低于阴性组（P<0.05）,H...

An investigation of Helicobacter pylori infection and potential risk factors of colonization found in 10661 cases from routine physical examination

Objective To investigate the situation of Helicobacter pylori(H.pylori)infection in healthy people and analyze the related risk factors.Methods Retrospective analysis was conducted on 10661 healthy subjects who underwent carbon 13-urea breath test(13C-UBT)on January 1,2019 to December 30,2020 in affiliated hospital of North Sichuan Medical College.According to the infection status of Helicobacter pylori(H.pylori),the subjects were divided into H.pylori positive group and H.pylori negative group.H.pylori infection and platelet(PLT),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),fasting blood glucose(FBG),T3,T4,TSH and pepsinogenⅠ(pepsinogenⅠ)were analyzed.PepsinogenⅠ,pepsinogenⅡ(pepsinogen),gastrin 17(G-17),homocysteine(Hcy),uric acid(UA)and total bilirubin(TBIL)were also examined.Results 1)The total number of positive infections:4382,the total positive rate:41.10%,including 2717 male positive cases with morbidity as 25.49%.There were 1665 cases of positive infection in females,and the morbidity was 15.62%,which was lower than that in males(P<0.05).2)Compared with the negative group,the age of the positive group was slightly lower than that of the negative group(P<0.05),and the HDL-C,pepsinogenⅠ/Ⅱ,Hcy and TBil were all lower than those of the negative group(P<0.05).BMI,SBP,DBP,TG,FBG,pepsinogenⅠ,pepsinogen and G-17 in H.pylori positive group were all higher than those in negative group(P<0.05).3)DOB value was correlated with age,FBG,pepsinogenⅠ,pepsinogen,G-17,pepsinogen Ano/Cha and TBil(P<0.001).4)The parameters P<0.05 were further included in binary Logistic regression analysis,and male,BMI,FBG,pepsinogenⅡ,pepsinogen branch/root were risk factors for H.pylori infection(P<0.05).ConclusionsH.pylori infection is more common in male population,BMI,FBG,pepsinogenⅡ,pepsinogen L/N are the risk factors for H.pylori infection.Early intervention of these risk factors is expected to reduce the infection of H.pylori and provide theoretical basis for the primary prevention of this gastrointestinal diseases.