磷酸肌酸钠对病毒性心肌炎患儿心功能及细胞免疫功能的影响

目的:观察磷酸肌酸钠对病毒性心肌炎患儿心功能及细胞免疫功能的影响,探讨磷酸肌酸钠在小儿病毒性心肌炎治疗中的临床应用价值。方法:选取我院2016年10月至2017年11月收治的65例病毒性心肌炎患儿,其中男32例,女33例。通过随机数表法分为对照组和观察组,对照组采用1,6二磷酸果糖0.2 g/ (kg·d) 治疗,连续用药2-3周,观察组采用磷酸肌酸钠1.0 g/(kg·d)治疗,连续用药2-3周,比较两组患儿在心功能和细胞免疫功能上的疗效差异。结果:治疗前,观察组与对照组心功能指标左室射血分数(LVEF)、心室短轴缩短率(FS)和心脏指数(CI)比较差异无统计学意义(P>0.05);治疗后,观察组心功能指标LVEF、FS、CI 较对照组升高,差异有统计学意义( P<0.05)。治疗前,观察组与对照组细胞免疫功能指标CD3+、CD4+、CD8+、NK细胞水平比较差异无统计学意义(P>0.05);治疗后,观察组CD3+、CD4+、CD8+、NK细胞水平较对照组升高,差异有统计学意义(P<0.05)。结论:磷酸肌酸钠可明显提高病毒性心肌炎患儿的心功能及细胞免疫功能,临床治疗效果理想,具有推广应用价值。

Creatine Phosphate Sodium on Cardiac Function and Cellular Immune Function in Children with Viral Myocarditis

Objective: To observe the effects of creatine phosphate sodium on cardiac function and cellular immune function in childrenwith viral myocarditis, and to probe into the clinical application value of creatine phosphate sodium in the treatment of viral myocarditis. Methods: Totally 65 children with viral myocarditis admitted into our hospital from Oct.2016 to Nov.2017 were extracted, including 32 males and 33 females. All patients were randomly divided into the control group and the observation group via the random number table, the control group was treated with fructose 1, 6 diphosphate 0.2 g/ (kg·d) for 2 to 3 weeks, the observation group received 1 g/(kg·d) of sodium creatine phosphate for 2 to 3 weeks. Differences in cardiac function and cellular immune function between two groups were compared. Results: Before treatment, there was no significant difference in left ventricular ejection fraction(LVEF), fraction shortening (FS) and cardiac index(CI) between the observation group and the control group (P>0.05). After treatment, the LVEF, FS, and CI of the observation group were significantly higher than those of the control group, with statistically significant difference (P<0.05). Before treatment, there was no significant difference in the levels of CD3+, CD4+, CD8+ and NK cells between the observation group and the control group (P>0.05). After treatment, the levels of CD3+, CD4+, CD8+ and NK cells in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: Creatine phosphate sodium can significantly improve the heart function and cellular immune function of children with viral myocarditis, and the clinical treatment effect is remarkable and has promotion value.