妊娠多形疹患者血清嗜酸性粒细胞和总IgE检测的临床意义

目的 探讨妊娠多形疹患者进行血清嗜酸性粒细胞和总IgE检测的临床意义。方法 选取2013年1月至2016年12月广东省妇幼保健院收治的66例妊娠多形疹患者为观察组，观察组患者确诊后即检测血清嗜酸性粒细胞和总IgE水平；在产科门诊正常孕妇人群中，随机选取与观察组患者孕周相同的70例孕妇为对照组，并检测其血清嗜酸性粒细胞和总IgE水平；比较观察组和对照组血清嗜酸性粒细胞和总IgE水平差异。观察组患者在治疗初期给予外用糠酸莫米松软膏，治疗2周后皮损或瘙痒无明显改善的患者进一步给予口服泼尼松龙，比较观察组患者在治疗前后血清嗜酸性粒细胞和总IgE水平变化情况。结果 观察组治疗前的血清嗜酸性粒细胞和总IgE水平均高于对照组[（319.7±86.2）×10⁶/L比（114.3±68.5）×10⁶/L；（581.9±144.2）U/mL比（89.4±23.6）U/mL]，差异有统计学意义（P<0.05）；局部外用糠酸莫米松软膏后，51例有效患者和15例无效患者治疗前后的血清嗜酸性粒细胞和总IgE水平对比，差异无统计学意义（P>0.05）；口服泼尼松龙治疗后，15例外用药治疗无效的患者症状均得到改善，与治疗前相比，血清嗜酸性粒细胞和总IgE水平降低，差异有统计学意义（P<0.05）；并且其与51例外用药有效患者相比，血清嗜酸性粒细胞和总IgE水平在治疗前后差值有统计学意义（P<0.05）。结论 妊娠多形疹患者的血清嗜酸性粒细胞和总IgE水平高于正常孕妇，经系统治疗后症状改善且血清嗜酸性粒细胞和总IgE水平较治疗前下降。

Clinical significance of detection of serum eosinophils and total IgE in patients with polymorphic eruption of pregnancy

Objective To investigate the clinical significance of the levels of serum eosinophils and total IgE in patients with polymorphic eruption of pregnancy(PEP). Methods From Jan 2013 to Dec 2016, 66 patients with PEP were selected as observation group in Guangdong Women and Children Hospital, and the serum eosinophils and total IgE levels were measured immediately after diagnosis. 70 normal pregnant women of the same gestational age as the observation group were randomly selected as the control group and the serum eosinophil and total IgE levels were measured. The serum eosinophil and total IgE levels were compared between the observation group and the control group. The patients in the observation group were given the topical Mometasone ointment at the beginning of treatment, and the patients with no significant improvement in skin lesion or pruritus after 2 weeks were further given oral prednisolone. The changes of serum eosinophil and total IgE were compared before and after treatment. Results The serum eosinophil and total IgE levels in the observation group were higher than those in the control group[319.7±86.2)×10⁶/L vs (114.3±68.5)×10⁶/L;(581.9±144.2) U/mL vs (89.4±23.6) U/mL], with significant differences between them (P<0. 05). There was no statistically significant difference in serum eosinophil and total IgE levels between before and after topical treatment of effective and ineffective patients(P>0.05). After oral prednisolone treatment, the symptoms of 15 patients with ineffective topical treatment were improved, and the levels of serum eosinophils and total IgE were decreased compared with those before treatment,and their differences were all statistically significant(P<0.05). Comparing 15 patients with oral prednisolone treatment and 51 patients with an effective topical treatment,the difference between before and after treatment was statistically significant (P<0.05). Conclusion The serum eosinophil and total IgE levels in patients with PEP were higher than those in normal pregnant women. The symptoms of patients improved after oral prednisolone therapy and the serum eosinophil and total IgE levels were lower than those before treatment.