| 海南地区妊娠期高血压疾病患者母婴HLA-DRB1基因共享率研究* |
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| 引用本文： | 韩贞艳,陈建林,关红琼,张程圆,韦秋圆. 海南地区妊娠期高血压疾病患者母婴HLA-DRB1基因共享率研究*[J]. 中国现代医学杂志, 2019, 29(13): 37-40 |
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| 作者姓名： | 韩贞艳 陈建林 关红琼 张程圆 韦秋圆 |
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| 作者单位： | （1.海南医学院第二附属医院 产科，海南 海口 570311；2.中南大学湘雅二医院 妇产科，湖南 长沙 410011） |
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| 基金项目： | 海南省卫生计生行业科研项目（No：琼卫科教[2017]3号） |
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| 摘 要： |
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| 收稿时间： | 2018-12-11 |
HLA-DRB1 gene frequency in maternity and infant in hypertensive disorder of pregnancy* |
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| Zhen-yan Han,Jian-lin Chen,Hong-qiong Guan,Cheng-yuan Zhang,Qiu-yuan Wei. HLA-DRB1 gene frequency in maternity and infant in hypertensive disorder of pregnancy*[J]. China Journal of Modern Medicine, 2019, 29(13): 37-40 |
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| Authors: | Zhen-yan Han Jian-lin Chen Hong-qiong Guan Cheng-yuan Zhang Qiu-yuan Wei |
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| Affiliation: | (1. Department of Obstetrics, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China; 2. Department of Gynecology and Obstetrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China) |
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| Abstract: | Objective To investigate the rate of HLA-DRB1 gene sharing in maternal fetuses with pregnancy-induced hypertension (HDP) in Hainan Province. Methods A total of 50 cases of HDP and 50 healthy individuals were involved in this study. HLA-DRB1 was genotyped using the HLA Genotyping Assay Kit (PCR-SBT). Results There was no significant difference in HLA-DRB1 antigen between healthy group and HDP group (P?>?0.05). In HDP group, 0, 45 and 5 cases shared 0, 1 and 2 DR antigens, respectively. In the control group, 1, 44 and 5 cases patients shared 0, 1 and 2 DR antigens. There was no significant difference in the number of maternal and fetal antigen sharing between the two groups (P?>?0.05). Conclusions No obvious difference in rate of maternal-fetal HLA-DRB1 gene among HDP pregnant women and healthy individuals. |
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| Keywords: | pregnancy, hypertension human leukocyte antigen allele HLA-DRB1 |
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