扶正颗粒治疗宫颈癌同步放化疗后白细胞减少的疗效研究

目的探讨扶正颗粒治疗宫颈癌同步放化疗后白细胞减少的临床效果和安全性。方法选取2018年7月至2020年7月于本院就诊的68例宫颈癌同步放化疗后白细胞减少患者,按随机数字表法分为两组,各34例。对照组予以重组人粒细胞刺激因子治疗,观察组采用扶正颗粒治疗。比较两组临床疗效、白细胞计数(WBC)和中性粒细胞计数(NT)、中医症候积分、不良反应发生情况。结果观察组治疗总有效率为94.12%,高于对照组的76.47%,差异有统计学意义(P<0.05);观察组WBC、NT均高于对照组,差异有统计学意义(P<0.05);观察组神疲乏力、头晕、胸闷和纳差积分均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.88%,低于对照组的26.47%,差异有统计学意义(P<0.05)。结论扶正颗粒可提高宫颈癌同步放化疗后白细胞减少患者的治疗效果,加快WBC复常,减轻神疲乏力等症状,且不良反应少,安全性高。

Effect of Fuzheng granules on leukopenia after concurrent radiotherapy and chemotherapy for cervical cancer

Objective To investigate the clinical effect and safety of Fuzheng granules in treating cervical cancer with leukopenia after concurrent radiotherapy and chemotherapy. Methods 68 cervical cancer patients with leukopenia after concurrent radiotherapy and chemotherapy were selected in our hospital from July 2018 to July 2020, and they were divided into two groups according to random number table method, with 34 cases in each group. The control group was treated with recombinant human granulocyte stimulating factor, and the observation group was treated with Fuzheng granules. The clinical efficacy, white blood cell count(WBC) and neutrophil count(NT), TCM syndrome score, and occurrence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 94.12%, which was higher than 76.47% in the control group, the difference was statistically significant(P<0.05);WBC and NT in the observation group were higher than those in the control group, the difference was statistically significant(P<0.05);the scores of fatigue, dizziness, chest tightness and anorexia in the observation group were lower than those in the control group, the difference was statistically significant(P<0.05);the adverse reaction rate in the observation group was 5.88%, which was lower than 26.47% in the control group, the difference was statistically significant(P<0.05). Conclusion Fuzheng granules can improve the therapeutic effect of patients with leukocytopenia after concurrent radiotherapy and chemotherapy for cervical cancer, speed up the recovery of WBC, relieve symptoms such as fatigue and fatigue, and have fewer adverse reactions and the safety is high.