前列地尔联合阿托伐他汀治疗老年急性脑梗死伴颅内动脉狭窄的疗效及对相关炎性因子水平的影响

目的探讨前列地尔联合阿托伐他汀治疗老年急性脑梗死伴颅内动脉狭窄的疗效及对相关炎性因子水平的影响。方法选取本院2018年6月至2019年6月收治的80例老年急性脑梗死合并颅内动脉狭窄患者作为研究对象,按随机数字法分为对照组与观察组,各40例。对照组给予阿托伐他汀钙片治疗,观察组给予阿托伐他汀钙片联合前列地尔注射液治疗。比较两组治疗前后炎性因子(IL-2、IL-6、IL-8)水平及血脂指标(TG、TC、HDL-C、LDL-C)的变化情况。结果治疗后,观察组IL-2、IL-6、IL-8水平均明显低于治疗前,并明显低于对照组(P<0.05)。治疗后,观察组TG、TC、LDL-C水平均显著低于对照组,HDL-C水平高于对照组(P<0.05)。结论前列地尔联合阿托伐他汀治疗老年急性脑梗死合并颅内动脉狭窄患者,可显著改善患者血脂水平,降低炎症反应。

Effect of alprostadil combined with atorvastatin in the treatment of acute cerebral infarction with intracranial artery stenosis in the elderly and its influence on the level of related inflammatory factors

Objective To explore the therapeutic effect of alprostadil combined with atorvastatin on senile acute cerebral infarction with intracranial artery stenosis and its influence on the level of related inflammatory factors. Methods 80 elderly patients with acute cerebral infarction combined with intracranial artery stenosis from June 2018 to June 2019 in our hospital were selected as the reseach subjects. According to the random number method, they were divided into the control group and the observation group, with 40 cases in each group. The control group was treated with atorvastatin, while the observation group was treated with atorvastatin combined with alprostadil injection. The levels of inflammatory factors(IL-2, IL-6, IL-8) and the changes of blood lipid indexes(TG, TC, HDL-C, LDL-C) were compared before and after treatment between two groups. Results The levels of IL-2, IL-6 and IL-8 in the observation group were significantly lower than those before treatment, and significantly lower than that in the control group(P<0.05). The levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group, and the levels of HDL-C were higher than those in the control group(P<0.05). Conclusion The combination therapy of alprostadil and atorvastatin in elderly patients with acute cerebral infarction complicated with intracranial artery stenosis can significantly improve the blood lipid level and reduce inflammation.