脑出血与脑梗死患者血脂和血清脂蛋白谱的比较

目的：观察脑出血与脑梗死患者血脂和血清脂蛋白谱的变化及其特点。方法：选择脑出血患者59例，脑梗死患者21例以及健康对照30例，测定血清甘油三脂（TG），总胆固醇（TC），高密度脂蛋白胆固醇（HDLC），极低密度脂蛋白胆固醇（VLDLC）和低密度脂蛋白胆固醇（LDLC），并用改良双梯度聚丙烯酰胺凝胶电泳法测定了血清脂蛋白谱（SLPG）。结果：脑梗死组TC，LDLC高于对照组，脑出血组LDLC高于对照组，低于脑梗死组；SLPG结果显示脑梗死组α脂蛋白（αLP），β脂蛋白（βLP），中间β脂蛋白（intβLP)高于对照组，脑出血组βLP，intβLP高于对照组，差别有统计学意义。逐步判别分析优选出βLP，intβLP,HDLC为判别脑血管病（CVD）的指标，这三项指标对CVD的判对率为71．3％，结论：βLP，intBLP，HDLC可作为临床预测脑血管病的重要指标。

Comparative study of serum lipids and serum lipoprotein spectrum in patients with cerebrovascular diseases.

OBJECTIVE: To investigate the differences of serum lipids and serum lipoprotein spectrum between patients with cerebral hemorrhage (CH) and cerebral infarction (CI), and study their features of expression in the 2 cerebral conditions. METHODS: Serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very-low-density lipoprotein cholesterol (vLDLC), low-density lipoprotein cholesterol (LDLC) and serum lipoprotein electrophoretogram were determined in 59 CI and 21 CH patients as well as in 30 normal subjects. RESULTS: CI patients had higher levels of TC, LDLC, alpha-lipoprotein (alpha LP), beta-lipoprotein (beta LP) and intermediate-density beta-lipoprotein (int beta LP) than the normal subjects, and the CH patients had lower LDLC level than the CI patients. The CH patients had also higher levels of beta LP, int beta LP and LDLC than the normal subjects. Progressive regression analysis was performed and resulted in the selection of beta LP, int beta LP and HDLC as the best discriminators for cerebral vascular diseases, which were valid in classifying 71.3% of the cases included in this study. CONCLUSION: beta LP, int beta LP and HDLC are important clinical indicators to predict cerebral vascular diseases.