Glucocorticosteroids in allergic inflammation: Clinical benefits in otitis media with effusion |
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Authors: | Ingeborg Dhooge MD PhD Katia Verbruggen MD Liesbet Vandenbulcke MD |
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Affiliation: | (1) Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium |
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Abstract: | Allergy and otitis media with effusion are often considered as comorbidities. Evidence points to a role for allergy in the pathogenesis of otitis media with effusion in reports of increased prevalence of allergy in patients with otitis media with effusion and presence of late-phase allergic-response inflammatory mediators and cytokines in the middle-ear effusion of allergic subjects. However, the exact mechanism remains unknown. Many speculations have been made, but well-controlled studies to prove the efficacy of anti-allergic medication in the treatment of otitis media with effusion are lacking. Therefore, we do not recommend the use of glucocorticosteroids in allergic patients with otitis media with effusion. |
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