Rubella-associated hemophagocytic syndrome in an infant |
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Authors: | Baykan Ali Akcakus Mustafa Deniz Kemal |
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Affiliation: | Department of Pediatrics, Division of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey. abaykan@erciyes.edu.tr |
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Abstract: | Hemophagocytic syndrome (HPS) is a fulminant disorder characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes in the lymphoreticular tissues. The characteristic pathologic feature is reactive histiocytic hyperplasia with leukoerythrophagocytosis in a variety of organs. This disorder occurs most often in patients in whom the immune system is compromised and has been associated with a variety of infectious agents, including viruses, bacteria, mycobacteria, spirochetes, fungi, and parasites. The authors describe a 2.5-month-old girl with rubella-associated HPS, demonstrated by postmortem liver necropsy. |
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