A new experimental flap design: the saphenous artery periosto-fasciocutaneous flap of the rat |
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Authors: | Bayramiçli Mehmet Ersoy Burak Sirino?lu Hakan |
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Institution: | Marmara üniversitesi Hastanesi, Plastik ve Rekonstrüktif Cerrahi A.D., Fevzi ?akmak mahallesi, Pendik, Istanbul, Turkey. |
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Abstract: | Vascularized periosteal graft is a frequently applied flap model for bone prefabrication studies due to its inhabitance of osteoprogenitor cells and osteoinductive potential. Various bones such as rib and fibula are reported as a potential source for the harvest of the periosteal flap in experimental studies on higher species such as dogs and pigs, which necessitates a rather complicated and expensive experimental setting. Therefore a reliable and inexpensive small animal model on vascularized periosteal flaps is necessary for future research. A new saphenous artery based periosto-fasciocutaneous flap model in rats is described here, which is easily dissected and monitorized. In this experimental study, 15 male Sprague Dawley rats were operated and killed following a 3-month-long follow-up period . The histological analysis revealed heterotopic osteoneogenesis in 12 of 15 flaps (80%), whereas 14 flaps (93.3%) exhibited signs of angioneogenesis originating from the periostofasciocutaneous flap. The presented flap model promises to be an appropriate alternative for new studies where bone prefabrication methods are evaluated. |
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